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Favorable outcome of COVID-19 in a young woman with severe Crohn's disease on regular use of adalimumab and prednisone: a case report.
Vechi, Hareton Teixeira; Maia, Lucas Rodrigues; Alves, Manoela do Monte; Rodrigues-Neto, João Firmino.
  • Vechi HT; Universidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas do Rio Grande do Norte, Caicó, Rio Grande do Norte, Brazil.
  • Maia LR; Universidade Federal do Rio Grande do Norte, Faculdade de Medicina, Natal, Rio Grande do Norte, Brazil.
  • Alves MDM; Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Departamento de Infectologia, Natal, Rio Grande do Norte, Brazil.
  • Rodrigues-Neto JF; Universidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas do Rio Grande do Norte, Caicó, Rio Grande do Norte, Brazil.
Rev Inst Med Trop Sao Paulo ; 62: e102, 2020.
Article in English | MEDLINE | ID: covidwho-983846
ABSTRACT
COVID-19 is a viral disease caused by SARS-CoV-2 that compromises the host immune response in severe cases, promoting a hyperinflammation that results in acute lung injury and multiple organs failure. In this context, patients presenting with immune-related diseases, such as Crohn's disease, affected by COVID-19, may have an uncertain prognosis. We report on a case of a young female patient with a severe Crohn's disease that presented with COVID-19 pneumonia and a favorable outcome even maintaining the use of adalimumab, TNF - alpha inhibitor and prednisone. This case raises the hypothesis that aside from prednisone, TNF-α inhibitors such as adalimumab could be used to stop the progression to COVID-19 complications by blocking the TNF-alpha-driven inflammatory process that occurs in severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prednisone / Crohn Disease / Adalimumab / COVID-19 Type of study: Case report / Prognostic study Limits: Female / Humans Language: English Journal: Rev Inst Med Trop Sao Paulo Year: 2020 Document Type: Article Affiliation country: S1678-9946202062102

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prednisone / Crohn Disease / Adalimumab / COVID-19 Type of study: Case report / Prognostic study Limits: Female / Humans Language: English Journal: Rev Inst Med Trop Sao Paulo Year: 2020 Document Type: Article Affiliation country: S1678-9946202062102