Sterols and Triterpenes: Antiviral Potential Supported by In-Silico Analysis
Plants
; 10(1):41, 2021.
Article
in English
| ScienceDirect | ID: covidwho-984379
ABSTRACT
The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortunately, there is no specific treatment for COVID-19 so far. Herbal medicines and purified natural products can provide a rich resource for novel antiviral drugs. Therefore, in this review, we focused on the sterols and triterpenes as potential candidates derived from natural sources with well-reported in vitro efficacy against numerous types of viruses. Moreover, we compiled from these reviewed compounds a library of 162 sterols and triterpenes that was subjected to a computer-aided virtual screening against the active sites of the recently reported SARS-CoV-2 protein targets. Interestingly, the results suggested some compounds as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics.
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Collection:
Databases of international organizations
Database:
ScienceDirect
Language:
English
Journal:
Plants
Year:
2021
Document Type:
Article
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