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Two-step analysis of the COVID19 pandemic:has the virus reduced its lethality?
Italian Journal of Medicine ; 14(SUPPL 2):116, 2020.
Article in English | EMBASE | ID: covidwho-984747
ABSTRACT
Background and Aim of the study In the course of the epidemic,COVID 19 disease first appeared severely and then with a gradualreduction in symptoms. Aim of the study was to compare the clinical characteristics of patients hospitalized in two different periodsfrom March to May.Materials and

Methods:

174 patients, 161 subjects admitted inthe period March 17 / April 17 and 13 subjects admitted in theperiod April 17 / May 17, at the Covid Unit of F. Miulli Hospital inAcquaviva delle Fonti (Ba), were studied.

Results:

From the comparison of the two periods, there is a clearreduction in hospitalizations (161 vs 13). The number of asymptomatic or mildly complicated patients is significantly greater inthe second group. The rate of patients hospitalized with severepneumonia (19.9%) or ARDS (6.8%) in the first period is higherthan the patients of the second period (7.7% and 0%). In March/ April, 3.1% of patients needed ICU admission while no patientwas admitted to ICU in the past thirty days. The length of stay wasalso significantly higher in the first period (21 ± 8 days vs 8 ± 2days) as well as mortality (14% vs 11%). IL 6, d-dimers and fibrinogen values were lower (but not statistically significant) in theApril / May period.Discussion and

Conclusions:

Our sample, although of limitedsize, shows a significant difference in the clinical evolution of theCOVID 19 infection in the two study periods. The reduction inlength of stay, severe respiratory failure and mortality indicate alikely attenuation in coronavirus virulence in the last month of thepandemic spread.
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Collection: Databases of international organizations Database: EMBASE Language: English Journal: Italian Journal of Medicine Year: 2020 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Language: English Journal: Italian Journal of Medicine Year: 2020 Document Type: Article