Technical routes for coronavirus vaccine development

ABSTRACT

Three types of coronavirus, SARS-CoV, MERS-CoV, and SARS-CoV-2, are known to cause severe diseases in humans and cause outbreaks or epidemics. After the outbreak of the epidemic, a number of institutions around the world carried out coronavirus related vaccine research and development, and the vaccines are mainly divided into five types inactivated virus vaccine, alive-attenuated vaccine, gene recombination subunit vaccine, viral vector vaccine and nucleic acid vaccine. In this review, the progress in coronavirus vaccine development was summarized by analyzing the global research of coronavirus vaccine.