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Anti-heart antibodies levels and their correlation with clinical symptoms and outcomes in patients with confirmed or suspected diagnosis COVID-19.
Blagova, Olga; Varionchik, Nadezhda; Zaidenov, Vladimir; Savina, Polina; Sarkisova, Natalia.
  • Blagova O; The First I.M. Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Varionchik N; The First I.M. Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Zaidenov V; Moscow City Clinical Hospital No. 52, Moscow, Russia.
  • Savina P; The First I.M. Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Sarkisova N; The First I.M. Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.
Eur J Immunol ; 51(4): 893-902, 2021 04.
Article in English | MEDLINE | ID: covidwho-986037
ABSTRACT
The aim of this study is to evaluate the blood level of anti-heart antibodies (AHA) and its correlation with clinical outcomes in patients with severe and moderate coronavirus disease 2019 (COVID-19). The study included 34 patients (23 males; mean age 60.2 ± 16.6 years) with COVID-19 pneumonia. Besides standard medical examination, the AHA blood levels were observed, including antinuclear antibodies, antiendothelial cell antibodies, anti-cardiomyocyte antibodies (AbC), anti-smooth muscle antibodies (ASMA), and cardiac conducting tissue antibodies. Median hospital length of stay was 14 [13; 18] days. AHA levels were increased in 25 (73.5%) patients. Significant correlation (p < 0.05) of AHA levels with cardiovascular manifestations (r = 0.459) was found. AbC levels correlated with pneumonia severity (r = 0.472), respiratory failure (r = 0.387), need for invasive ventilation (r = 0.469), chest pain (r = 0.374), low QRS voltage (r = 0.415), and levels of C-reactive protein (r = 0.360) and lactate dehydrogenase (r = 0.360). ASMA levels were found to correlate with atrial fibrillation (r = 0.414, p < 0.05). Antinuclear antibodies and AbC levels correlated with pericardial effusion (r = 0.721 and r = 0.745, respectively, p < 0.05). The lethality rate was 8.8%. AbC and ASMA levels correlated significantly with lethality (r = 0.363 and r = 0.426, respectively, p < 0.05) and were prognostically important. AHA can be considered as part of the systemic immune and inflammatory response in COVID-19. Its possible role in the inflammatory heart disease requires further investigation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Antinuclear / Myocytes, Cardiac / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048930

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Antinuclear / Myocytes, Cardiac / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202048930