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Liver disease and poor outcomes of COVID-19 hospitalizations-a meta-analysis
Hepatology ; 72(1 SUPPL):283A-284A, 2020.
Article in English | EMBASE | ID: covidwho-986145
ABSTRACT

Background:

COVID-19 pandemic has been a challenge with globally 12,567,457 coronavirus cases reported and 561,879 deaths as of July 11, 2020 Isolated small studies have reported the prevalence of comorbid chronic liver disease (CM-CLD) and COVID-19 associated acute liver injury (COVID-19-ALI) in hospitalized patients In this metaanalysis, we assessed the association of comorbid liver disease and acute liver injury and outcomes in COVID-19 hospitalized patients

Methods:

Observational studies describing the CM-CLD and COVID-19-ALI and outcomes of COVID-19 hospitalized patients from December 1, 2019, to June 30, 2020, were identified. Data was extracted following MOOSE guidelines with a consensus of four independent reviewers. Adverse outcomes were defined as admission to intensive care unit (ICU), oxygen saturation <90%, invasive mechanical ventilation (IMV), severe disease and in-hospital mortality Data was analysed using Review Manager 5 4 The odds ratio (OR) and 95% confidence interval (95%CI) were obtained and forest plots were created using randomeffects models The p value <0 05 was considered statistically significant.

Results:

12 studies with 7564 confirmed COVID-19 patients were included Out of these, 12 studies (7564 patients) and 3 studies (146 patients) provided data on CM-CLD and COVID-19-ALI, respectively The pooled prevalence of CM-CLD was 2 67% [(202/7564)∗d COVID-19-ALI was 22 6% [(33/146)∗ patients with poor outcomes, the prevalence of CM-CLD was 2 4%(54/2233) and COVID-19-ALI was 32% (18/56) In meta-analysis, CM-CLD had no significant association with poor outcomes (OR0 89;95%CI0 65-1 22;p=0 47) with no heterogeneity in the data (p=0 93;I2=0%) COVID-19-ALI had higher odds of poor outcomes with OR of 2 49 (95%CI1 09-5 69;p=0 03) and without any significant heterogeneity between studies (p=0 67;I2=0%)

Conclusion:

Our meta-analysis suggests that acute liver injury was significantly associated with COVID-19 severity and poor outcomes Future studies should evaluate changing levels of biomarkers amongst liver disease patients to predict poor outcomes of COVID-19.

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Reviews Language: English Journal: Hepatology Year: 2020 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Reviews Language: English Journal: Hepatology Year: 2020 Document Type: Article