Liver disease and poor outcomes of COVID-19 hospitalizations-a meta-analysis
Hepatology
; 72(1 SUPPL):283A-284A, 2020.
Article
in English
| EMBASE | ID: covidwho-986145
ABSTRACT
Background:
COVID-19 pandemic has been a challenge with globally 12,567,457 coronavirus cases reported and 561,879 deaths as of July 11, 2020 Isolated small studies have reported the prevalence of comorbid chronic liver disease (CM-CLD) and COVID-19 associated acute liver injury (COVID-19-ALI) in hospitalized patients In this metaanalysis, we assessed the association of comorbid liver disease and acute liver injury and outcomes in COVID-19 hospitalized patientsMethods:
Observational studies describing the CM-CLD and COVID-19-ALI and outcomes of COVID-19 hospitalized patients from December 1, 2019, to June 30, 2020, were identified. Data was extracted following MOOSE guidelines with a consensus of four independent reviewers. Adverse outcomes were defined as admission to intensive care unit (ICU), oxygen saturation <90%, invasive mechanical ventilation (IMV), severe disease and in-hospital mortality Data was analysed using Review Manager 5 4 The odds ratio (OR) and 95% confidence interval (95%CI) were obtained and forest plots were created using randomeffects models The p value <0 05 was considered statistically significant.Results:
12 studies with 7564 confirmed COVID-19 patients were included Out of these, 12 studies (7564 patients) and 3 studies (146 patients) provided data on CM-CLD and COVID-19-ALI, respectively The pooled prevalence of CM-CLD was 2 67% [(202/7564)∗d COVID-19-ALI was 22 6% [(33/146)∗ patients with poor outcomes, the prevalence of CM-CLD was 2 4%(54/2233) and COVID-19-ALI was 32% (18/56) In meta-analysis, CM-CLD had no significant association with poor outcomes (OR0 89;95%CI0 65-1 22;p=0 47) with no heterogeneity in the data (p=0 93;I2=0%) COVID-19-ALI had higher odds of poor outcomes with OR of 2 49 (95%CI1 09-5 69;p=0 03) and without any significant heterogeneity between studies (p=0 67;I2=0%)Conclusion:
Our meta-analysis suggests that acute liver injury was significantly associated with COVID-19 severity and poor outcomes Future studies should evaluate changing levels of biomarkers amongst liver disease patients to predict poor outcomes of COVID-19.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
Language:
English
Journal:
Hepatology
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS