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Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience.
Madhusoodhan, P Pallavi; Pierro, Joanna; Musante, Jordan; Kothari, Prachi; Gampel, Bradley; Appel, Burton; Levy, Adam; Tal, Adit; Hogan, Laura; Sharma, Archana; Feinberg, Shari; Kahn, Alissa; Pinchinat, Ashley; Bhatla, Teena; Glasser, Chana L; Satwani, Prakash; Raetz, Elizabeth A; Onel, Kenan; Carroll, William L.
  • Madhusoodhan PP; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Pierro J; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Hassenfeld Children's Hospital at NYU Langone Health, Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York.
  • Musante J; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Kothari P; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gampel B; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, New York.
  • Appel B; Children's Cancer Institute, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, New Jersey.
  • Levy A; Department of Pediatrics, Division of Pediatric Hematology/Oncology and Cellular Therapy, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
  • Tal A; Department of Pediatrics, Division of Pediatric Hematology/Oncology and Cellular Therapy, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
  • Hogan L; Department of Pediatrics, Stony Brook Children's Hospital, Stony Brook, New York.
  • Sharma A; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
  • Feinberg S; Department of Pediatrics, Division of Pediatric Hematology-Oncology at Maimonides Cancer Center, Maimonides Medical Center, Brooklyn, New York.
  • Kahn A; The Valerie Fund Center at St. Joseph's Children's Hospital, Paterson, New Jersey.
  • Pinchinat A; Department of Pediatrics, Division of Hematology, Oncology, and Stem Cell Transplantation, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York.
  • Bhatla T; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Children's Hospital of New Jersey at Newark Beth Israel Medical Center, Newark, New Jersey.
  • Glasser CL; Department of Pediatrics, Division of Pediatric Hematology-Oncology, NYU Winthrop Hospital, NYU Long Island School of Medicine, Mineola, New York.
  • Satwani P; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, New York.
  • Raetz EA; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Hassenfeld Children's Hospital at NYU Langone Health, Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York.
  • Onel K; Departments of Genetics and Genomic Sciences, Medicine, Pathology, and Pediatrics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Carroll WL; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Hassenfeld Children's Hospital at NYU Langone Health, Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York.
Pediatr Blood Cancer ; 68(3): e28843, 2021 03.
Article in English | MEDLINE | ID: covidwho-986383
ABSTRACT

PURPOSE:

Pediatric oncology patients undergoing active chemotherapy are suspected to be at a high risk for severe disease secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection; however, data to support this are lacking. We aim to describe the characteristics of coronavirus disease 2019 (COVID-19) in this population and also its impact on pediatric cancer care in the New York region during the peak of the pandemic. PATIENTS AND

METHODS:

This multicenter, retrospective study included 13 institutions. Clinical and laboratory information on 98 patients ≤21 years of age receiving active anticancer therapy, who tested positive for SARS-CoV-2 by nasopharyngeal swab polymerase chain reaction (PCR), was collected.

RESULTS:

Of the 578 pediatric oncology patients tested for COVID-19, 98 were positive, of whom 73 were symptomatic. Most experienced mild disease, 28 required inpatient management, 25 needed oxygen support, and seven required mechanical ventilation. There is a slightly higher risk of severe disease in males and obese patients, though not statistically significant. Persistent lymphopenia was noted in severe cases. Delays in cancer therapy occurred in 67% of SARS-CoV-2-positive patients. Of four deaths, none were solely attributable to COVID-19. The impact of the pandemic on pediatric oncology care was significant, with 54% of institutions reporting delays in chemotherapy, 46% delays in surgery, and 30% delays in transplant.

CONCLUSION:

In this large multi-institutional cohort, we observed that mortality and morbidity from COVID-19 amongst pediatric oncology patients were low overall, but higher than reported in general pediatrics. Certain subgroups might be at higher risk of severe disease. Delays in cancer care due to SARS-CoV-2 remain a concern.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / COVID-19 / Neoplasms / Antineoplastic Agents Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / COVID-19 / Neoplasms / Antineoplastic Agents Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2021 Document Type: Article