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[COVID-19 and the kidneys-Clinical aspects]. / COVID-19 und die Niere ­ Klinik: Wie die Nephrologie die klinische und intensivmedizinische Versorgung der Patienten fundamental verbessert.
Gross, Oliver.
  • Gross O; Klinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Robert-Koch Str. 40, 37075 Göttingen, Deutschland.
Nephrologe ; : 1-6, 2020 Dec 11.
Article in German | MEDLINE | ID: covidwho-986660
Semantic information from SemMedBD (by NLM)
1. Organ LOCATION_OF 2019 novel coronavirus
Subject
Organ
Predicate
LOCATION_OF
Object
2019 novel coronavirus
2. Serum albumin low result PROCESS_OF Patients
Subject
Serum albumin low result
Predicate
PROCESS_OF
Object
Patients
3. Extracellular Fluid PART_OF Lung
Subject
Extracellular Fluid
Predicate
PART_OF
Object
Lung
4. Extracellular Fluid PART_OF Patients
Subject
Extracellular Fluid
Predicate
PART_OF
Object
Patients
5. Hypoalbuminemia PROCESS_OF Patients
Subject
Hypoalbuminemia
Predicate
PROCESS_OF
Object
Patients
6. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
7. intensive care TREATS Critical Illness
Subject
intensive care
Predicate
TREATS
Object
Critical Illness
8. intensive care TREATS Patients
Subject
intensive care
Predicate
TREATS
Object
Patients
9. Organ LOCATION_OF 2019 novel coronavirus
Subject
Organ
Predicate
LOCATION_OF
Object
2019 novel coronavirus
10. Serum albumin low result PROCESS_OF Patients
Subject
Serum albumin low result
Predicate
PROCESS_OF
Object
Patients
11. Extracellular Fluid PART_OF Lung
Subject
Extracellular Fluid
Predicate
PART_OF
Object
Lung
12. Extracellular Fluid PART_OF Patients
Subject
Extracellular Fluid
Predicate
PART_OF
Object
Patients
13. Hypoalbuminemia PROCESS_OF Patients
Subject
Hypoalbuminemia
Predicate
PROCESS_OF
Object
Patients
14. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
15. intensive care TREATS Critical Illness
Subject
intensive care
Predicate
TREATS
Object
Critical Illness
16. intensive care TREATS Patients
Subject
intensive care
Predicate
TREATS
Object
Patients
ABSTRACT
The aim of this article is to explain the clinical benefits of the growing knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to the lungs, SARS-CoV­2 can invade multiple cell types in other organs, such as the kidneys and replicate there. Important damaging pathways of the virus, such as vascular endotheliitis, thrombotic events and systemic cytokine release are still incompletely understood. Coronavirus disease 2019 (COVID-19) is a systemic disease that necessitates intensive medical care and in particular, internal medicine involvement and represents a major challenge for all disciplines of internal medicine. Among these, nephrology in particular is involved in the fight against COVID-19 in a variety of ways urine investigations can provide indications of multiple organ involvement, endotheliitis, microthrombi and microcirculation damage, etc. Experience with low serum albumin levels and antithrombin III activity in nephrotic patients helps to point out the decreasing effects of loop diuretics and heparin to other specialist disciplines. Nephrological knowledge of the complications of hypoalbuminemia and "resistance" to diuretics must lead to an early implementation of renal replacement procedures in order to be able to prevent mechanical ventilation in COVID-19 intensive care patients with increased extracellular lung fluid. The kidneys can be used as a seismograph for severe courses of COVID-19 and nephrological knowledge can be brought to use to optimize the intensive medical care for critically ill patients. Both together have the potential to considerably reduce morbidity and mortality further.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Clinical Practice Guide Language: German Journal: Nephrologe Clinical aspect: Etiology / Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Clinical Practice Guide Language: German Journal: Nephrologe Clinical aspect: Etiology / Prognosis Year: 2020
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