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A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder.
Kotnala, Sudhir; Dhasmana, Anupam; Kashyap, Vivek K; Chauhan, Subhash C; Yallapu, Murali M; Jaggi, Meena.
  • Kotnala S; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
  • Dhasmana A; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
  • Kashyap VK; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
  • Chauhan SC; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
  • Yallapu MM; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
  • Jaggi M; Department of Immunology and Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA. Electronic address: meena.jaggi@ut
Life Sci ; 268: 118959, 2021 Mar 01.
Article in English | MEDLINE | ID: covidwho-988728
Semantic information from SemMedBD (by NLM)
1. Disease ASSOCIATED_WITH Mutation
Subject
Disease
Predicate
ASSOCIATED_WITH
Object
Mutation
2. Mutation PROCESS_OF Cystic Fibrosis Transmembrane Conductance Regulator
Subject
Mutation
Predicate
PROCESS_OF
Object
Cystic Fibrosis Transmembrane Conductance Regulator
3. Cystic Fibrosis AFFECTS Inflammatory Response
Subject
Cystic Fibrosis
Predicate
AFFECTS
Object
Inflammatory Response
4. MULTISYSTEM DISORDER AFFECTS Comorbidity
Subject
MULTISYSTEM DISORDER
Predicate
AFFECTS
Object
Comorbidity
5. Respiration Disorders COEXISTS_WITH Cystic Fibrosis
Subject
Respiration Disorders
Predicate
COEXISTS_WITH
Object
Cystic Fibrosis
6. Epithelium LOCATION_OF Destructive procedure (surgical)
Subject
Epithelium
Predicate
LOCATION_OF
Object
Destructive procedure (surgical)
7. Glycoproteins AFFECTS Disease
Subject
Glycoproteins
Predicate
AFFECTS
Object
Disease
8. paired basic amino acid cleaving enzyme ADMINISTERED_TO Cells
Subject
paired basic amino acid cleaving enzyme
Predicate
ADMINISTERED_TO
Object
Cells
9. Disease ASSOCIATED_WITH Mutation
Subject
Disease
Predicate
ASSOCIATED_WITH
Object
Mutation
10. Mutation PROCESS_OF Cystic Fibrosis Transmembrane Conductance Regulator
Subject
Mutation
Predicate
PROCESS_OF
Object
Cystic Fibrosis Transmembrane Conductance Regulator
11. Cystic Fibrosis AFFECTS Inflammatory Response
Subject
Cystic Fibrosis
Predicate
AFFECTS
Object
Inflammatory Response
12. MULTISYSTEM DISORDER AFFECTS Comorbidity
Subject
MULTISYSTEM DISORDER
Predicate
AFFECTS
Object
Comorbidity
13. Respiration Disorders COEXISTS_WITH Cystic Fibrosis
Subject
Respiration Disorders
Predicate
COEXISTS_WITH
Object
Cystic Fibrosis
14. Epithelium LOCATION_OF Destructive procedure (surgical)
Subject
Epithelium
Predicate
LOCATION_OF
Object
Destructive procedure (surgical)
15. Glycoproteins AFFECTS Disease
Subject
Glycoproteins
Predicate
AFFECTS
Object
Disease
16. paired basic amino acid cleaving enzyme ADMINISTERED_TO Cells
Subject
paired basic amino acid cleaving enzyme
Predicate
ADMINISTERED_TO
Object
Cells
ABSTRACT
Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves in the inflammatory processes and is considered as a multisystem disorder that is not confined to lungs, but it also affects other vital organs that leads to numerous co-morbidities. The respiratory disorder in the CF results in mortality and morbidity which is characterized by series of serious events involving mucus hypersecretion, microbial infections, airways obstruction, inflammation, destruction of epithelium, tissue remodeling and terminal lung diseases. Mucins are the high molecular weight glycoproteins important for the viscoelastic properties of the mucus, play a significant role in the disease mechanisms. Determining the functional association between the CFTR and mucins might help to identify the putative target for specific therapeutic approach. In fact, furin enzyme which helps in the entry of novel COVID-19 virus into the cell, is upregulated in CF and this can also serve as a potential target for CF treatment. Moreover, the use of nano-formulations for CF treatment is an area of research being widely studied as they have also demonstrated promising outcomes. The in-depth knowledge of non-coding RNAs like miRNAs and lncRNAs and their functional association with CFTR gene expression and mutation can provide a different range of opportunity to identify the promising therapeutic approaches for CF.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis / COVID-19 Limits: Animals / Humans Language: English Journal: Life Sci Year: 2021 Document Type: Article Affiliation country: J.lfs.2020.118959

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis / COVID-19 Limits: Animals / Humans Language: English Journal: Life Sci Year: 2021 Document Type: Article Affiliation country: J.lfs.2020.118959