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The Assessment of Convalescent Plasma Efficacy against COVID-19.
Casadevall, Arturo; Grossman, Brenda J; Henderson, Jeffrey P; Joyner, Michael J; Shoham, Shmuel; Pirofski, Liise-Anne; Paneth, Nigel.
  • Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
  • Grossman BJ; Departments of Medicine and Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Henderson JP; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Joyner MJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Shoham S; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Pirofski LA; Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Paneth N; Departments of Department of Epidemiology & Biostatistics and Pediatrics & Human Development, Michigan State University, East Lansing, MI, USA.
Med (N Y) ; 1(1): 66-77, 2020 12 18.
Article in English | MEDLINE | ID: covidwho-988791
ABSTRACT
Antibody-based therapy for infectious diseases predates modern antibiotics and, in the absence of other therapeutic options, was deployed early in the SARS-CoV-2 pandemic through COVID-19 convalescent plasma (CCP) administration. Although most studies have demonstrated signals of efficacy for CCP, definitive assessment has proved difficult under pandemic conditions, with rapid changes in disease incidence and the knowledge base complicating the design and implementation of randomized controlled trials. Nevertheless, evidence from a variety of studies demonstrates that CCP is as safe as ordinary plasma and strongly suggests that it can reduce mortality if given early and with sufficient antibody content.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Med (N Y) Year: 2020 Document Type: Article Affiliation country: J.medj.2020.11.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Med (N Y) Year: 2020 Document Type: Article Affiliation country: J.medj.2020.11.002