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Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.
Zhang, Qian; Bastard, Paul; Bolze, Alexandre; Jouanguy, Emmanuelle; Zhang, Shen-Ying; Cobat, Aurélie; Notarangelo, Luigi D; Su, Helen C; Abel, Laurent; Casanova, Jean-Laurent.
  • Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Bastard P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Bolze A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
  • Jouanguy E; University of Paris, Imagine Institute, Paris, France.
  • Zhang SY; Helix, San Mateo, CA, USA.
  • Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
  • Notarangelo LD; University of Paris, Imagine Institute, Paris, France.
  • Su HC; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
  • Casanova JL; University of Paris, Imagine Institute, Paris, France.
Med (N Y) ; 1(1): 14-20, 2020 12 18.
Article in English | MEDLINE | ID: covidwho-988793
ABSTRACT
The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Med (N Y) Year: 2020 Document Type: Article Affiliation country: J.medj.2020.12.001

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Med (N Y) Year: 2020 Document Type: Article Affiliation country: J.medj.2020.12.001