Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients.
Med Hypotheses
; 147: 110475, 2021 Feb.
Article
in English
| MEDLINE | ID: covidwho-988867
ABSTRACT
Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2's intracellular latency. Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response, endothelial homeostasis and a non-prothrombotic platelet activation status, we propose that impairment in selenocysteine synthesis, via perturbations in the aforementioned physiological functions, potentially constitutes a mechanism of coagulopathy in COVID 19 patients other than those developed in critical illness.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Coagulation Disorders
/
Selenocysteine
/
SARS-CoV-2
/
COVID-19
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Med Hypotheses
Year:
2021
Document Type:
Article
Affiliation country:
J.mehy.2020.110475
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