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The role of obesity in inflammatory markers in COVID-19 patients.
McNeill, Jenna N; Lau, Emily S; Paniagua, Samantha M; Liu, Elizabeth E; Wang, Jessica K; Bassett, Ingrid V; Selvaggi, Caitlin A; Lubitz, Steven A; Foulkes, Andrea S; Ho, Jennifer E.
  • McNeill JN; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, United States.
  • Lau ES; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
  • Paniagua SM; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
  • Liu EE; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
  • Wang JK; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States.
  • Bassett IV; Division Infectious Disease, Massachusetts General Hospital, Boston, MA, United States; Mongan Institute, Massachusetts General Hospital, Boston, MA, United States.
  • Selvaggi CA; The Biostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
  • Lubitz SA; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
  • Foulkes AS; The Biostatistics Center, Massachusetts General Hospital, Boston, MA, United States.
  • Ho JE; The Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States; Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States. Electronic address: jho1@mgh.harvard.edu.
Obes Res Clin Pract ; 15(1): 96-99, 2021.
Article in English | MEDLINE | ID: covidwho-988981
ABSTRACT
Obesity has emerged as a significant risk factor for severe COVID-19 worldwide. Given both COVID-19 infection and obesity have been associated with increased systemic inflammation, we evaluated inflammatory markers in obese and non-obese individuals hospitalized for COVID-19 at Massachusetts General Hospital. We hypothesized that obese patients would have a more exuberant inflammatory response as evidenced by higher initial and peak inflammatory markers along with worse clinical outcomes. Of the 781 patients, 349 were obese (45%). Obese individuals had higher initial and peak levels of CRP and ESR as well as higher peak d-dimer (P < 0.01 for all) in comparison to non-obese individuals, while. IL-6 and ferritin were similar. In addition, obese individuals had a higher odds of requiring vasopressor use (OR 1.54, 95% CI 1.00-2.38, P = 0.05), developing hypoxemic respiratory failure (OR 1.58, 95% CI 1.04-2.40, P = 0.03) and death (OR 2.20, 95% CI 1.31-3.70, P = 0.003) within 28 days of presentation to care. Finally, higher baseline levels of CRP and D-dimer were associated with worse clinical outcomes even after adjustment for BMI. Our findings suggest greater disease severity in obese individuals is characterized by more exuberant inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Blood Sedimentation / C-Reactive Protein / Fibrin Fibrinogen Degradation Products / COVID-19 / Inflammation / Obesity Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Obes Res Clin Pract Year: 2021 Document Type: Article Affiliation country: J.orcp.2020.12.004

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Blood Sedimentation / C-Reactive Protein / Fibrin Fibrinogen Degradation Products / COVID-19 / Inflammation / Obesity Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Obes Res Clin Pract Year: 2021 Document Type: Article Affiliation country: J.orcp.2020.12.004