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COVID-19, ferrosenescence and neurodegeneration, a mini-review.
Sfera, Adonis; Osorio, Carolina; Maguire, Gerald; Rahman, Leah; Afzaal, Jafri; Cummings, Michael; Maldonado, Jose Campo.
  • Sfera A; Patton State Hospital, California, United States of America. Electronic address: Adonis.Sfera@dsh.ca.gov.
  • Osorio C; Loma Linda University, Loma Linda, United States of America.
  • Maguire G; University of California, Riverside, United States of America.
  • Rahman L; Patton State Hospital, California, United States of America.
  • Afzaal J; Patton State Hospital, California, United States of America.
  • Cummings M; Patton State Hospital, California, United States of America.
  • Maldonado JC; University of Texas, Rio Grande Valley, United States of America.
Prog Neuropsychopharmacol Biol Psychiatry ; 109: 110230, 2021 07 13.
Article in English | MEDLINE | ID: covidwho-989032
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
3. Hyperferritinemia COEXISTS_WITH Disease
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
Disease
4. Causative_agents PROCESS_OF Older people
Subject
Causative_agents
Predicate
PROCESS_OF
Object
Older people
5. Genom CAUSES C0007581
Subject
Genom
Predicate
CAUSES
Object
C0007581
6. Ability PREDISPOSES Immune System Diseases
Subject
Ability
Predicate
PREDISPOSES
Object
Immune System Diseases
7. Ability PREDISPOSES Neurodegenerative Disorders
Subject
Ability
Predicate
PREDISPOSES
Object
Neurodegenerative Disorders
8. Therapeutic procedure TREATS Complication
Subject
Therapeutic procedure
Predicate
TREATS
Object
Complication
9. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
12. Hyperferritinemia COEXISTS_WITH Disease
Subject
Hyperferritinemia
Predicate
COEXISTS_WITH
Object
Disease
13. Causative_agents PROCESS_OF Older people
Subject
Causative_agents
Predicate
PROCESS_OF
Object
Older people
14. Genome, Human CAUSES Cellular Senescence
Subject
Genome, Human
Predicate
CAUSES
Object
Cellular Senescence
15. Ability PREDISPOSES Immune System Diseases
Subject
Ability
Predicate
PREDISPOSES
Object
Immune System Diseases
16. Ability PREDISPOSES Neurodegenerative Disorders
Subject
Ability
Predicate
PREDISPOSES
Object
Neurodegenerative Disorders
17. Therapeutic procedure TREATS Complication
Subject
Therapeutic procedure
Predicate
TREATS
Object
Complication
18. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
ABSTRACT
Exacerbation of cognitive, motor and nonmotor symptoms have been described in critically ill COVID-19 patients, indicating that, like prior pandemics, neurodegenerative sequelae may mark the aftermath of this viral infection. Moreover, SARS-CoV-2, the causative agent of COVID-19 disease, was associated with hyperferritinemia and unfavorable prognosis in older individuals, suggesting virus-induced ferrosenescence. We have previously defined ferrosenescence as an iron-associated disruption of both the human genome and its repair mechanisms, leading to premature cellular senescence and neurodegeneration. As viruses replicate more efficiently in iron-rich senescent cells, they may have developed the ability to induce this phenotype in host tissues, predisposing to both immune dysfunction and neurodegenerative disorders. In this mini-review, we summarize what is known about the SARS-CoV-2-induced cellular senescence and iron dysmetabolism. We also take a closer look at immunotherapy with natural killer cells, angiotensin II receptor blockers ("sartans"), iron chelators and dipeptidyl peptidase 4 inhibitors ("gliptins") as adjunct treatments for both COVID-19 and its neurodegenerative complications.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cellular Senescence / Iron Metabolism Disorders / Neurodegenerative Diseases / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Prog Neuropsychopharmacol Biol Psychiatry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cellular Senescence / Iron Metabolism Disorders / Neurodegenerative Diseases / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Prog Neuropsychopharmacol Biol Psychiatry Year: 2021 Document Type: Article