Prognostic implications of myocardial injury in patients with and without COVID-19 infection treated in a university hospital.
Rev Esp Cardiol (Engl Ed)
; 74(1): 24-32, 2021 Jan.
Article
in English, Spanish
| MEDLINE | ID: covidwho-989111
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Cardiac troponin, a marker of myocardial injury, is frequently observed in patients with COVID-19 infection. Our objective was to analyze myocardial injury and its prognostic implications in patients with and without COVID-19 infection treated in the same period of time.METHODS:
The present study included patients treated in a university hospital with cardiac troponin I measurements and with suspected COVID-19 infection, confirmed or ruled out by polymerase chain reaction analysis. The impact was analyzed of cardiac troponin I positivity on 30-day mortality.RESULTS:
In total, 433 patients were distributed among the following groups confirmed COVID-19 (n=186), 22% with myocardial injury (n=41); and ruled out COVID-19 (n=247), 21.5% with myocardial injury (n=52). The confirmed and ruled out COVID-19 groups had a similar age, sex, and cardiovascular history. Mortality was significantly higher in the confirmed COVID-19 group than in the ruled out group (19.9% vs 5.3%, P <.001). In Cox multivariate regression analysis, cardiac troponin I was a predictor of mortality in both groups (confirmed COVID-19 group HR, 3.54; 95%CI, 1.70-7.34; P=.001; ruled out COVID-19 group HR, 5.57; 95%CI, 1.70-18.20; P=.004). The predictive model analyzed by ROC curves was similar in the 2 groups (P=.701), with AUCs of 0.808 in the confirmed COVID-19 group (0.750-0.865) and 0.812 in the ruled out COVID-19 group (0.760-0.864).CONCLUSIONS:
Myocardial injury is detected in 1 in every 5 patients with confirmed or ruled out COVID-19 and predicts 30-day mortality to a similar extent in both circumstances.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Troponin I
/
SARS-CoV-2
/
COVID-19
/
Cardiomyopathies
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
/
Spanish
Journal:
Rev Esp Cardiol (Engl Ed)
Year:
2021
Document Type:
Article
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