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COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease.
Fernandez-Ruiz, Ruth; Paredes, Jacqueline L; Niewold, Timothy B.
  • Fernandez-Ruiz R; Division of Rheumatology, NYU Grossman School of Medicine, New York, New York; Colton Center for Autoimmunity, New York University School of Medicine, New York, New York. Electronic address: Ruth.FernandezRuiz@nyulangone.org.
  • Paredes JL; Colton Center for Autoimmunity, New York University School of Medicine, New York, New York.
  • Niewold TB; Colton Center for Autoimmunity, New York University School of Medicine, New York, New York.
Transl Res ; 232: 13-36, 2021 06.
Article in English | MEDLINE | ID: covidwho-989350
ABSTRACT
As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a growing need to assess its impact in patients with autoimmune rheumatic diseases, such as systemic lupus erythematosus (SLE). Patients with SLE are a unique population when considering the risk of contracting COVID-19 and infection outcomes. The use of systemic glucocorticoids and immunosuppressants, and underlying organ damage from SLE are potential susceptibility factors. Most patients with SLE have evidence of high type I interferon activity, which may theoretically act as an antiviral line of defense or contribute to the development of a deleterious hyperinflammatory response in COVID-19. Other immunopathogenic mechanisms of SLE may overlap with those described in COVID-19, thus, studies in SLE could provide some insight into immune responses occurring in severe cases of the viral infection. We reviewed the literature to date on COVID-19 in patients with SLE and provide an in-depth review of current research in the area, including immune pathway activation, epidemiology, clinical features, outcomes, and the psychosocial impact of the pandemic in those with autoimmune disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Lupus Erythematosus, Systemic Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Transl Res Journal subject: Medicine / Laboratory Techniques and procedures Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Lupus Erythematosus, Systemic Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Transl Res Journal subject: Medicine / Laboratory Techniques and procedures Year: 2021 Document Type: Article