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Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19.
Zhao, Guolian; Xu, Yazhou; Li, Jing; Cui, Xiaoli; Tan, Xiaowen; Zhang, Hongyue; Dang, Liyun.
  • Zhao G; Department of Laboratory Medicine, Xi'an Chest Hospital, Xi'an, China.
  • Xu Y; Department of Etio-biology, Southern Medical University, Guangzhou, China.
  • Li J; Reproductive Medical Center, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Cui X; Department of Laboratory Medicine, Xi'an Chest Hospital, Xi'an, China.
  • Tan X; Department of Laboratory Medicine, Xi'an Chest Hospital, Xi'an, China.
  • Zhang H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
  • Dang L; Department of Laboratory Medicine, Xi'an Chest Hospital, Xi'an, China.
Biosci Rep ; 41(1)2021 01 29.
Article in English | MEDLINE | ID: covidwho-1174708
ABSTRACT
Millions of people infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been diagnosed with coronavirus infectious disease 2019 (COVID-19). The prevalence and severity of COVID-19 differ between sexes. To explain these differences, we analyzed clinical features and laboratory values in male and female COVID-19 patients. The present study included a cohort of 111 people, i.e. 36 COVID-19 patients, 54 sex- and age-matched common viral community-acquired pneumonia (CAP) patients, and 21 healthy controls. Monocyte counts, lymphocyte subset counts, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and C-reactive protein (CRP) levels in the peripheral blood were analyzed. Higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, monocyte counts, and CRP and ALT levels were found in male COVID-19 patients. Decreased lymphocyte subset counts and proportions were observed in COVID-19 patients, except for the CD3+ and CD8+ T cell proportions. The lower CD4+ T cell proportions and higher CD8+ T cell proportions were observed in male and severe COVID-19 patients and the differences were independent of estrogen level. The CD4+ T cell proportion was negatively associated with the CD8+ T cell proportion in male COVID-19 patients; this correlation was non-significant in females. Our work demonstrates differences between sexes in circulating monocyte counts and CD4+ T cell and CD8+ T cell proportions in COVID-19 patients, independent of estrogen levels, are associated with the clinical manifestations in COVID-19 patients with high specificity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Monocytes / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bsr20202074

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Monocytes / SARS-CoV-2 / COVID-19 / Immunity, Innate Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bsr20202074