To cut or not to cut: New rules for proteolytic shedding of membrane proteins.
J Biol Chem
; 295(35): 12353-12354, 2020 08 28.
Article
in English
| MEDLINE | ID: covidwho-990137
ABSTRACT
Sheddases are specialized proteases that control the abundance and function of membrane proteins by cleaving their substrate's extracellular domain (ectodomain), a process known as shedding. Hundreds of shedding substrates have been identified, but little is known about the mechanisms that govern ectodomain shedding. Iwagishi et al. now report that negatively charged amino acids in the membrane-proximal juxtamembrane domain of substrates make them resistant to shedding by the metalloprotease ADAM17. These findings will help researchers better understand the regulation of shedding and may aid in the development of drugs targeting sheddases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
ADAM Proteins
/
Membrane Proteins
Language:
English
Journal:
J Biol Chem
Year:
2020
Document Type:
Article
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