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Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic.
Strich, Jeffrey R; Ramos-Benitez, Marcos J; Randazzo, Davide; Stein, Sydney R; Babyak, Ashley; Davey, Richard T; Suffredini, Anthony F; Childs, Richard W; Chertow, Daniel S.
  • Strich JR; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Ramos-Benitez MJ; United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.
  • Randazzo D; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Stein SR; Light Imaging Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA.
  • Babyak A; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Davey RT; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Suffredini AF; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Childs RW; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Chertow DS; United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.
J Infect Dis ; 223(6): 981-984, 2021 03 29.
Article in English | MEDLINE | ID: covidwho-990724
ABSTRACT
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxazines / Pyridines / Extracellular Traps / COVID-19 Drug Treatment / Neutrophils Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxazines / Pyridines / Extracellular Traps / COVID-19 Drug Treatment / Neutrophils Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis