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No cases of asymptomatic SARS-CoV-2 infection among healthcare staff in a city under lockdown restrictions: lessons to inform 'Operation Moonshot'.
Martin, Christopher A; Jenkins, David R; Patel, Prashanth; Goss, Charles; Price, Arthur; Barton, Linda; Gupta, Pankaj; Zaccardi, Francesco; Brunskill, Nigel J; Haldar, Pranab; Khunti, Kamlesh; Pareek, Manish.
  • Martin CA; Department of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Jenkins DR; Department of Infection and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Patel P; Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Goss C; Department of Chemical Pathology and Metabolic Diseases, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Price A; Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Barton L; Department of Occupational Health, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Gupta P; Department of Immunology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Zaccardi F; Department of Haematology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Brunskill NJ; Department of Chemical Pathology and Metabolic Diseases, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
  • Haldar P; Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK.
  • Khunti K; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester LE5 4PW, UK.
  • Pareek M; Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester LE5 4PW, UK.
J Public Health (Oxf) ; 2020 Dec 26.
Article in English | MEDLINE | ID: covidwho-990793
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Staff
Subject
COVID-19
Predicate
PROCESS_OF
Object
Staff
2. Uptake PROCESS_OF Staff
Subject
Uptake
Predicate
PROCESS_OF
Object
Staff
3. COVID-19 PROCESS_OF Staff
Subject
COVID-19
Predicate
PROCESS_OF
Object
Staff
4. Uptake PROCESS_OF Staff
Subject
Uptake
Predicate
PROCESS_OF
Object
Staff
ABSTRACT

BACKGROUND:

Leicester was the first city in the UK to have 'local lockdown' measures imposed in response to high community rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. As part of this response, a directive was issued by NHS England to offer testing of asymptomatic healthcare workers (HCWs) at University Hospitals of Leicester NHS Trust (UHL) for SARS-CoV-2 infection.

METHODS:

Between 20 July and 14 August 2020, we invited all HCWs at UHL to attend for SARS-CoV-2 testing by nucleic acid amplification (NAAT). We combined the result of this assay with demographic information from the electronic staff record.

RESULTS:

A total of 1150 staff (~8% of the workforce) volunteered. The median age was 46 years (IQR 34-55), 972 (84.5%) were female; 234 (20.4%) were of South Asian and 58 (5.0%) of Black ethnicity; 564 (49.0%) were nurses/healthcare assistants. We found no cases of asymptomatic infection. In comparison, average community test positivity rate in Leicester city was 2.6%.

CONCLUSIONS:

Within the context of local lockdowns due to high community transmission rates, voluntary testing of asymptomatic staff has low uptake and low yield and thus its premise and cost-effectiveness should be re-considered.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Year: 2020 Document Type: Article Affiliation country: Pubmed

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Year: 2020 Document Type: Article Affiliation country: Pubmed