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Spices to Control COVID-19 Symptoms: Yes, but Not Only….
Bousquet, Jean; Czarlewski, Wienczyslawa; Zuberbier, Torsten; Mullol, Joaquim; Blain, Hubert; Cristol, Jean-Paul; De La Torre, Rafael; Le Moing, Vincent; Pizarro Lozano, Nieves; Bedbrook, Anna; Agache, Ioana; Akdis, Cezmi A; Canonica, G Walter; Cruz, Alvaro A; Fiocchi, Alessandro; Fonseca, Joao A; Fonseca, Susana; Gemicioglu, Bilun; Haahtela, Tari; Iaccarino, Guido; Ivancevich, Juan Carlos; Jutel, Marek; Klimek, Ludger; Kuna, Piotr; Larenas-Linnemann, Désirée E; Melén, Erik; Okamoto, Yoshitaka; Papadopoulos, Nikolaos G; Pfaar, Oliver; Reynes, Jacques; Rolland, Yves; Rouadi, Philip W; Samolinski, Boleslaw; Sheikh, Aziz; Toppila-Salmi, Sanna; Valiulis, Arunas; Choi, Hak-Jong; Kim, Hyun Ju; Anto, Josep M.
  • Bousquet J; Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany, jean.bousquet@orange.fr.
  • Czarlewski W; University hospital and MACVIA France, Montpellier, France, jean.bousquet@orange.fr.
  • Zuberbier T; Medical Consulting Czarlewski, Levallois, France.
  • Mullol J; MASK-air, Montpellier, France.
  • Blain H; Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany.
  • Cristol JP; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clinic-Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Spain.
  • De La Torre R; Department of Geriatrics, Montpellier University Hospital, Montpellier, France.
  • Le Moing V; Laboratoire de Biochimie et Hormonologie, PhyMedExp, Université de Montpellier, INSERM, CNRS, CHU de Montpellier, Montpellier, France.
  • Pizarro Lozano N; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain.
  • Bedbrook A; Maladies Infectieuses et Tropicales, CHU, Montpellier, France.
  • Agache I; IMIM (Hospital del Mar Research Institute), Barcelona, Spain.
  • Akdis CA; Autonomous University of Barcelona, Bellaterra, Barcelona, Spain.
  • Canonica GW; University hospital and MACVIA France, Montpellier, France.
  • Cruz AA; MASK-air, Montpellier, France.
  • Fiocchi A; Faculty of Medicine, Transylvania University, Brasov, Romania.
  • Fonseca JA; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich-Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
  • Fonseca S; Department of Biomedical Sciences, Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Humanitas University, Pieve Emanuele, Italy.
  • Gemicioglu B; Fundação ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
  • Haahtela T; Division of Allergy, Department of Pediatric Medicine-The Bambino Gesù Children's Research Hospital Holy see, Rome, Italy.
  • Iaccarino G; CINTESIS, Center for Research in Health Technologies and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal and MEDIDA, Lda, Porto, Portugal.
  • Ivancevich JC; GreenUPorto-Sustainable Agrifood Production Research Centre, DGAOT, Faculty of Sciences, University of Porto, Campus de Vairão, Vila do Conde, Portugal.
  • Jutel M; Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
  • Klimek L; Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland.
  • Kuna P; Department of Advanced Biomedical Sciences, Federico II University, Napoli, Italy.
  • Larenas-Linnemann DE; Interdepartmental Center of Research on Hypertension and Related Conditions CIRIAPA, Federico II University, Napoli, Italy.
  • Melén E; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
  • Okamoto Y; Department of Clinical Immunology, Wroclaw Medical University and ALL-MED Medical Research Institute, Wroclaw, Poland.
  • Papadopoulos NG; Center for Rhinology and Allergology, Wiesbaden, Germany.
  • Pfaar O; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
  • Reynes J; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, Mexico City, Mexico.
  • Rolland Y; Institute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
  • Rouadi PW; Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.
  • Samolinski B; Division of Infection, Allergy Department, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom.
  • Sheikh A; 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou," University of Athens, Athens, Greece.
  • Toppila-Salmi S; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Valiulis A; Maladies Infectieuses et Tropicales, CHU, Montpellier, France.
  • Choi HJ; Service de Gerontologie-CHU, Toulouse, France.
  • Kim HJ; Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
  • Anto JM; Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
Int Arch Allergy Immunol ; 182(6): 489-495, 2021.
Article in English | MEDLINE | ID: covidwho-992130
ABSTRACT
There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spices / Diet / NF-E2-Related Factor 2 / TRPA1 Cation Channel / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Int Arch Allergy Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spices / Diet / NF-E2-Related Factor 2 / TRPA1 Cation Channel / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Int Arch Allergy Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article