COVID-19 and children with Down syndrome: is there any real reason to worry? Two case reports with severe course.
BMC Pediatr
; 20(1): 561, 2020 12 18.
Article
in English
| MEDLINE | ID: covidwho-992454
ABSTRACT
BACKGROUND:
Down syndrome (DS) is characterized by a series of immune dysregulations, of which interferon hyperreactivity is important, as it is responsible for surging antiviral responses and the possible initiation of an amplified cytokine storm. This biological condition is attributed to immune regulators encoded in chromosome 21. Moreover, DS is also characterized by the coexistence of obesity and cardiovascular and respiratory anomalies, which are risk factors for coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). CASE PRESENTATION A total of 55 children were admitted to the pediatric ward in Bergamo, between February and May 2020 for COVID-19. Here, we describe the cases of two children with DS and a confirmed COVID-19 diagnosis who had a severe course. In addition, both cases involved one or more comorbidities, including cardiovascular anomalies, obesity, and/or obstructive sleep apnea.CONCLUSIONS:
Our observations indicate that children with DS are at risk for severe COVID-19 disease course.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Down Syndrome
/
COVID-19
Type of study:
Case report
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adolescent
/
Child, preschool
/
Female
/
Humans
Language:
English
Journal:
BMC Pediatr
Journal subject:
Pediatrics
Year:
2020
Document Type:
Article
Affiliation country:
S12887-020-02471-5
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