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Obesity and smoking as risk factors for invasive mechanical ventilation in COVID-19: A retrospective, observational cohort study.
Monteiro, Ana C; Suri, Rajat; Emeruwa, Iheanacho O; Stretch, Robert J; Cortes-Lopez, Roxana Y; Sherman, Alexander; Lindsay, Catherine C; Fulcher, Jennifer A; Goodman-Meza, David; Sapru, Anil; Buhr, Russell G; Chang, Steven Y; Wang, Tisha; Qadir, Nida.
  • Monteiro AC; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Suri R; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Emeruwa IO; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Stretch RJ; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Cortes-Lopez RY; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Sherman A; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Lindsay CC; Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Fulcher JA; Division of Infectious Disease, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Goodman-Meza D; Division of Infectious Disease, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Sapru A; Division of Critical Care, Department of Pediatrics, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Buhr RG; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Chang SY; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Wang T; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
  • Qadir N; Division of Pulmonary and Critical Care, Department of Medicine, UCLA Medical Center, Los Angeles, CA, United States of America.
PLoS One ; 15(12): e0238552, 2020.
Article in English | MEDLINE | ID: covidwho-992676
Preprint
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ABSTRACT

PURPOSE:

To describe the trajectory of respiratory failure in COVID-19 and explore factors associated with risk of invasive mechanical ventilation (IMV). MATERIALS AND

METHODS:

A retrospective, observational cohort study of 112 inpatient adults diagnosed with COVID-19 between March 12 and April 16, 2020. Data were manually extracted from electronic medical records. Multivariable and Univariable regression were used to evaluate association between baseline characteristics, initial serum markers and the outcome of IMV.

RESULTS:

Our cohort had median age of 61 (IQR 45-74) and was 66% male. In-hospital mortality was 6% (7/112). ICU mortality was 12.8% (6/47), and 18% (5/28) for those requiring IMV. Obesity (OR 5.82, CI 1.74-19.48), former (OR 8.06, CI 1.51-43.06) and current smoking status (OR 10.33, CI 1.43-74.67) were associated with IMV after adjusting for age, sex, and high prevalence comorbidities by multivariable analysis. Initial absolute lymphocyte count (OR 0.33, CI 0.11-0.96), procalcitonin (OR 1.27, CI 1.02-1.57), IL-6 (OR 1.17, CI 1.03-1.33), ferritin (OR 1.05, CI 1.005-1.11), LDH (OR 1.57, 95% CI 1.13-2.17) and CRP (OR 1.13, CI 1.06-1.21), were associated with IMV by univariate analysis.

CONCLUSIONS:

Obesity, smoking history, and elevated inflammatory markers were associated with increased need for IMV in patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Respiratory Insufficiency / COVID-19 / Obesity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0238552

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Respiratory Insufficiency / COVID-19 / Obesity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0238552