Your browser doesn't support javascript.
CNS implications of COVID-19: a comprehensive review.
Nagu, Priyanka; Parashar, Arun; Behl, Tapan; Mehta, Vineet.
  • Nagu P; Department of Pharmaceutics, Government College of Pharmacy, Rohru, District Shimla, Himachal Pradesh, India.
  • Parashar A; Faculty of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, District Shimla, Himachal Pradesh, India.
  • Behl T; Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
  • Mehta V; Department of Pharmacology, Government College of Pharmacy, Rohru 171207, District Shimla, Himachal Pradesh, India.
Rev Neurosci ; 32(2): 219-234, 2021 02 23.
Article in English | MEDLINE | ID: covidwho-992761
ABSTRACT
COVID-19 was first reported in December 2019 in the Wuhan city of China, and since then it has spread worldwide taking a heavy toll on human life and economy. COVID-19 infection is commonly associated with symptoms like coughing, fever, and shortness of breath, besides, the reports of muscle pain, anosmia, hyposmia, and loss of taste are becoming evident. Recent reports suggest the pathogenic invasion of the SARS-CoV-2 into the CNS, that could thereby result in devastating long term complications, primarily because some of these complications may go unnoticed for a long time. Evidence suggest that the virus could enter the CNS through angiotensin-converting enzyme-2 (ACE-2) receptor, neuronal transport, haematogenous route, and nasal route via olfactory bulb, cribriform plate, and propagates through trans-synaptic signalling, and shows retrograde movement into the CNS along nerve fiber. COVID-19 induces CNS inflammation and neurological degenerative damage through a diverse mechanism which includes ACE-2 receptor damage, cytokine-associated injury or cytokine storm syndrome, secondary hypoxia, demyelination, blood-brain barrier disruption, neurodegeneration, and neuroinflammation. Viral invasion into the CNS has been reported to show association with complications like Parkinsonism, Alzheimer's disorder, meningitis, encephalopathy, anosmia, hyposmia, anxiety, depression, psychiatric symptoms, seizures, stroke, etc. This review provides a detailed discussion of the CNS pathogenesis of COVID-19. Authors conclude that the COVID-19 cannot just be considered as a disorder of the pulmonary or peripheral system, rather it has a significant CNS involvement. Therefore, CNS aspects of the COVID-19 should be monitored very closely to prevent long term CNS complications, even after the patient has recovered from COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Central Nervous System / Stroke / SARS-CoV-2 / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0070

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Central Nervous System / Stroke / SARS-CoV-2 / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0070