Serum-soluble ST2 as a novel biomarker reflecting inflammatory status and illness severity in patients with COVID-19.
Biomark Med
; 14(17): 1619-1629, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-993122
ABSTRACT
Aim:
The authors studied the role of soluble ST2 (sST2) in COVID-19 and its relationship with inflammatory status and disease severity. Materials &methods:
Serum levels of sST2 and interleukin (IL)-33, C-reactive protein (CRP), serum amyloid protein (SAA), IL-6 and procalcitonin (PCT), and T lymphocyte subsets from 80 subjects diagnosed with COVID-19 including 36 mild, 41 severe and three asymptomatic cases were tested.Results:
Serum sST2 levels were significantly increased in COVID-19 patients, which were positively correlated with CRP, but negatively correlated with CD4+ and CD8+ T lymphocyte counts. Serum sST2 levels in nonsurviving severe cases were persistently high during disease progression.Conclusion:
Serum sST2 level test is helpful for reflecting inflammatory status and illness severity of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
CD4-Positive T-Lymphocytes
/
CD8-Positive T-Lymphocytes
/
Interleukin-1 Receptor-Like 1 Protein
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Biomark Med
Journal subject:
Biochemistry
/
Medicine
Year:
2020
Document Type:
Article
Affiliation country:
Bmm-2020-0410
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