Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD.
Front Med (Lausanne)
; 7: 615312, 2020.
Article
in English
| MEDLINE | ID: covidwho-993382
ABSTRACT
Background:
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19.Methods:
Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria.Results:
CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR7.04, 95% CI2.87-17.29; AKI/CKD HR5.25, 95% CI 2.29-12.02), followed by CKD subjects without AKI (HR3.39, 95% CI1.36-8.46). CKD status did not condition ICU admission or length of in-hospital stay.Conclusions:
CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Front Med (Lausanne)
Year:
2020
Document Type:
Article
Affiliation country:
Fmed.2020.615312
Similar
MEDLINE
...
LILACS
LIS