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Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD.
Coca, Armando; Burballa, Carla; Centellas-Pérez, Francisco Javier; Pérez-Sáez, María José; Bustamante-Munguira, Elena; Ortega, Agustín; Dueñas, Carlos; Arenas, María Dolores; Pérez-Martínez, Juan; Ruiz, Guadalupe; Crespo, Marta; Llamas, Francisco; Bustamante-Munguira, Juan; Pascual, Julio.
  • Coca A; Department of Nephrology, Hospital Clínico Universitario Valladolid, Valladolid, Spain.
  • Burballa C; Grupo de Trabajo de Jóvenes Nefrólogos de la Sociedad Española de Nefrología (JovSEN), Madrid, Spain.
  • Centellas-Pérez FJ; Grupo de Trabajo de Jóvenes Nefrólogos de la Sociedad Española de Nefrología (JovSEN), Madrid, Spain.
  • Pérez-Sáez MJ; Department of Nephrology, Hospital del Mar Barcelona, Barcelona, Spain.
  • Bustamante-Munguira E; Grupo de Trabajo de Jóvenes Nefrólogos de la Sociedad Española de Nefrología (JovSEN), Madrid, Spain.
  • Ortega A; Department of Nephrology and Renal Transplant, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • Dueñas C; Grupo de Trabajo de Jóvenes Nefrólogos de la Sociedad Española de Nefrología (JovSEN), Madrid, Spain.
  • Arenas MD; Department of Nephrology, Hospital del Mar Barcelona, Barcelona, Spain.
  • Pérez-Martínez J; Department of Intensive Care Medicine, Hospital Clínico Universitario Valladolid, Valladolid, Spain.
  • Ruiz G; Department of Nephrology and Renal Transplant, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • Crespo M; Department of Internal Medicine, Hospital Clínico Universitario Valladolid, Valladolid, Spain.
  • Llamas F; Department of Nephrology, Hospital del Mar Barcelona, Barcelona, Spain.
  • Bustamante-Munguira J; Department of Nephrology and Renal Transplant, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • Pascual J; Department of Clinical Chemistry, Hospital Clínico Universitario Valladolid, Valladolid, Spain.
Front Med (Lausanne) ; 7: 615312, 2020.
Article in English | MEDLINE | ID: covidwho-993382
Semantic information from SemMedBD (by NLM)
1. Chronic Kidney Diseases PROCESS_OF hospitalized patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
hospitalized patients
2. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
3. COVID-19 CAUSES Pneumonia
Subject
COVID-19
Predicate
CAUSES
Object
Pneumonia
4. Kidney Failur PROCESS_OF C0030705
Subject
Kidney Failur
Predicate
PROCESS_OF
Object
C0030705
5. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
6. White blood cell count increased (lab result) PROCESS_OF Patients
Subject
White blood cell count increased (lab result)
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 CAUSES Hospitalization
Subject
COVID-19
Predicate
CAUSES
Object
Hospitalization
8. Chronic Kidney Diseases PROCESS_OF hospitalized patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
hospitalized patients
9. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
10. COVID-19 CAUSES Pneumonia
Subject
COVID-19
Predicate
CAUSES
Object
Pneumonia
11. Kidney Failure, Chronic PROCESS_OF Patients
Subject
Kidney Failure, Chronic
Predicate
PROCESS_OF
Object
Patients
12. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
13. White blood cell count increased (lab result) PROCESS_OF Patients
Subject
White blood cell count increased (lab result)
Predicate
PROCESS_OF
Object
Patients
14. Kidney Failure, Acute PROCESS_OF Patients
Subject
Kidney Failure, Acute
Predicate
PROCESS_OF
Object
Patients
15. COVID-19 CAUSES Hospitalization
Subject
COVID-19
Predicate
CAUSES
Object
Hospitalization
ABSTRACT

Background:

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19.

Methods:

Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria.

Results:

CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR7.04, 95% CI2.87-17.29; AKI/CKD HR5.25, 95% CI 2.29-12.02), followed by CKD subjects without AKI (HR3.39, 95% CI1.36-8.46). CKD status did not condition ICU admission or length of in-hospital stay.

Conclusions:

CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fmed.2020.615312

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Language: English Journal: Front Med (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fmed.2020.615312