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Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19.
Cui, Wen; Yang, Kailin; Yang, Haitao.
  • Cui W; Institute of Life Sciences, Chongqing Medical University, Chongqing, China.
  • Yang K; School of Life Science and Technology, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
  • Yang H; Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, United States.
Front Mol Biosci ; 7: 616341, 2020.
Article in English | MEDLINE | ID: covidwho-993386
ABSTRACT
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19). This global healthcare emergency marked the third occurrence of a deadly coronavirus (CoV) into the human society after entering the new millennium, which overwhelmed the worldwide healthcare system and affected the global economy. However, therapeutic options for COVID-19 are still very limited. Developing drugs targeting vital proteins in viral life cycle is a feasible approach to overcome this dilemma. Main protease (Mpro) plays a dominant role in processing CoV-encoded polyproteins which mediate the assembly of replication-transcription machinery and is thus recognized as an ideal antiviral target. Here we summarize the recent progress in the discovery of anti-SARS-CoV-2 agents against Mpro. Combining structural study, virtual screen, and experimental screen, numerous therapeutic candidates including repurposed drugs and ab initio designed compounds have been proposed. Such collaborative effort from the scientific community would accelerate the pace of developing efficacious treatment for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Mol Biosci Year: 2020 Document Type: Article Affiliation country: Fmolb.2020.616341

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Mol Biosci Year: 2020 Document Type: Article Affiliation country: Fmolb.2020.616341