Development and head-to-head comparison of twocolloidal gold based serologiclateral flow assays for SARS-CoV-2 antibody tests
Nano Biomedicine and Engineering
; 12(4):306-310, 2020.
Article
in English
| EMBASE | ID: covidwho-993979
ABSTRACT
To combat the COVID-19 pandemic, serologic lateral flow immunoassays are required to facilitate accurate diagnosis of SARS-CoV-2 infection and confirmation of molecular results. This study evaluated sensitivity of two different designs of colloidal gold serologic tests (antigen based total antibody test and antibody based IgG test) by using residual serum samples from patients who were evaluated for SARS-CoV-2 infection status by polymerase chain reaction (PCR). The results showed 100% specificity for both tests, while when testing of 16 positive patients, the data showed 90% sensitivity for total antibody test and 30% for IgG test. This study demonstrates high diagnostic accuracy for anti-SARS-CoV-2 total antibody tests and will facilitate further development and selection of serological assays.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Nano Biomedicine and Engineering
Year:
2020
Document Type:
Article
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