Rapid evolution of our understanding of the pathogenesis of COVID-19: Implications for therapy.
S Afr Med J
; 110(12): 1180-1185, 2020 10 23.
Article
in English
| MEDLINE | ID: covidwho-994155
ABSTRACT
COVID-19 severity appears to lie in its propensity to cause a hyperinflammatory response, attributed to the cytokine release syndrome (CRS) or 'cytokine storm', although the exact role of the CRS remains to be fully elucidated. Hyperinflammation triggers a hypercoagulable state, also thought to play a key role in COVID-19 pathogenesis. Disease severity is linked to age, sex and comorbid conditions, which in turn may be linked to oxidative stress and pre-existing depletion of nicotinamide adenine dinucleotide (NAD+). There is increasing evidence that the host genome may determine disease outcome. Since most information pertaining to COVID-19 has thus far been extrapolated from the 'global North', similar studies in African populations are warranted. Many studies are aimed at finding a therapeutic strategy based on scientific rationale. Some promising results have emerged, e.g. the use of corticosteroids in severe acute respiratory distress syndrome (ARDS).
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombophilia
/
Cytokine Release Syndrome
/
COVID-19
/
Inflammation
Type of study:
Prognostic study
Language:
English
Journal:
S Afr Med J
Year:
2020
Document Type:
Article
Affiliation country:
SAMJ.2020.v110i12.15328
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