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PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID): rationale and protocol for a national multicenter observational study in The Netherlands.
Boers, Noor S; Botta, Michela; Tsonas, Annisa M; Algera, Anna Geke; Pillay, Janesh; Dongelmans, Dave A; Horn, Janneke; Vlaar, Alexander P J; Hollmann, Markus W; Bos, Lieuwe D J; Paulus, Frederique; Neto, Ary Serpa; Schultz, Marcus J.
  • Boers NS; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Botta M; Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location AMC, The Netherlands.
  • Tsonas AM; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Algera AG; Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location AMC, The Netherlands.
  • Pillay J; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Dongelmans DA; Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location AMC, The Netherlands.
  • Horn J; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Vlaar APJ; Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location AMC, The Netherlands.
  • Hollmann MW; Department of Critical Care, University Medical Center Groningen, University of Groningen, The Netherlands.
  • Bos LDJ; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Paulus F; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Neto AS; Department of Intensive Care, Amsterdam UMC location AMC, The Netherlands.
  • Schultz MJ; Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC location AMC, The Netherlands.
Ann Transl Med ; 8(19): 1251, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-994852
Semantic information from SemMedBD (by NLM)
1. Respiration PROCESS_OF Patients
Subject
Respiration
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PROCESS_OF
Object
Patients
2. Disease PROCESS_OF Patients
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Disease
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PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
Object
Patients
4. Practice Experience PROCESS_OF Patients
Subject
Practice Experience
Predicate
PROCESS_OF
Object
Patients
5. intensive care unit LOCATION_OF Multicenter Study
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intensive care unit
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LOCATION_OF
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Multicenter Study
6. Therapeutic procedure TREATS Hypoxemia
Subject
Therapeutic procedure
Predicate
TREATS
Object
Hypoxemia
7. Respiration PROCESS_OF Patients
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Respiration
Predicate
PROCESS_OF
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Patients
8. Disease PROCESS_OF Patients
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Disease
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PROCESS_OF
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Patients
9. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
10. Practice Experience PROCESS_OF Patients
Subject
Practice Experience
Predicate
PROCESS_OF
Object
Patients
11. intensive care unit LOCATION_OF Multicenter Study
Subject
intensive care unit
Predicate
LOCATION_OF
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Multicenter Study
12. Therapeutic procedure TREATS Hypoxemia
Subject
Therapeutic procedure
Predicate
TREATS
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Hypoxemia
ABSTRACT

BACKGROUND:

The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between and within countries and new insights are acquired rapidly. We aim to investigate invasive ventilation practices and outcome in COVID-19 patients in the Netherlands.

METHODS:

PRoVENT-COVID ('study of PRactice of VENTilation in COVID-19') is an investigator-initiated national, multicenter observational study to be undertaken in intensive care units (ICUs) in The Netherlands. Consecutive COVID-19 patients aged 18 years or older, who are receiving invasive ventilation in the participating ICUs, are to be enrolled during a 10-week period, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cmH2O) during the first 3 days of ventilation. Secondary outcomes include other ventilatory variables, use of rescue therapies for refractory hypoxemia such as prone positioning and extracorporeal membrane oxygenation, use of sedatives, vasopressors and inotropes; daily cumulative fluid balances; acute kidney injury; ventilator-free days and alive at day 28 (VFD-28), duration of ICU and hospital stay, and ICU, hospital and 90-day mortality.

DISCUSSION:

PRoVENT-COVID will be the largest observational study to date, with high density ventilatory data and major outcomes. There is urgent need for a better understanding of ventilation practices, and the effects of ventilator settings on outcomes in COVID-19 patients. The results of PRoVENT-COVID will be rapidly disseminated through electronic presentations, such as webinars and electronic conferences, and publications in international peer-reviewed journals. Access to source data will be made available through local, regional and national anonymized datasets on request, and after agreement of the PRoVENT-COVID steering committee. TRIAL REGISTRATION PRoVENT-COVID is registered at clinicaltrials.gov (identifier NCT04346342).
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Clinical Practice Guide / Prognostic study / Randomized controlled trials Language: English Journal: Ann Transl Med Year: 2020 Document Type: Article Affiliation country: ATM-20-5107

Full text: Available Collection: International databases Database: MEDLINE Type of study: Clinical Practice Guide / Prognostic study / Randomized controlled trials Language: English Journal: Ann Transl Med Year: 2020 Document Type: Article Affiliation country: ATM-20-5107