Neem (Azadiracta indica) a possible silver bullet in COVID 19

ABSTRACT

In past few years, multiple new viral diseases like SARS,MARS and Ebola are emerging all over the world. Due to global warming and pollution, people are becoming more susceptible to all infectious diseases. Recurrent mutations in these viruses make it difficult to create vaccine. So again there is need of safer and natural remedies which can help to sustain health of the present world and which can be used without potential hazards. The recent pandemic of Covid 19 is one of the example of a global crisis emerged by SARS-CoV-2 virus. It is causing acute as well as silent chronic damage to various systems in human body. Neem (Azadiracta indica) is found to have following properties as per various studies-It has Broad spectrum antiviral, antibacterial, antifun-gal, antiretroviral and antimalerial effect. It has proinflammatory cytokine inhibitor and immunomodulator effect. It has hepatoprotective and antioxi-dant effect. It has thrombolytic properties. It has ACE inhibitor action. As per its docking study, it has high inhibition against COVID-19 Main Protease. As Covid 19 is responsible for severe cytokine storm induced complications and coagulopathies, the Neem can be useful as a single Silver bullet in Covid 19 in both prophylactic and curative aspect. It can even be helpful in post Covid complications.