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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.
Sutter, Raoul; Hert, Lisa; De Marchis, Gian Marco; Twerenbold, Raphael; Kappos, Ludwig; Naegelin, Yvonne; Kuster, Gabriela M; Benkert, Pascal; Jost, Jasmine; Maceski, Aleksandra Maleska; Rüegg, Stephan; Siegemund, Martin; Leppert, David; Tschudin-Sutter, Sarah; Kuhle, Jens.
  • Sutter R; Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Hert L; Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • De Marchis GM; Medical Faculty, University of Basel, Basel, Switzerland.
  • Twerenbold R; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kappos L; Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Naegelin Y; Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kuster GM; Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Benkert P; Medical Faculty, University of Basel, Basel, Switzerland.
  • Jost J; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Maceski AM; Medical Faculty, University of Basel, Basel, Switzerland.
  • Rüegg S; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Siegemund M; Department of Cardiology, University Hospital Basel, Basel, Switzerland.
  • Leppert D; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
  • Tschudin-Sutter S; Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kuhle J; Medical Faculty, University of Basel, Basel, Switzerland.
Ann Neurol ; 89(3): 610-616, 2021 03.
Article in English | MEDLINE | ID: covidwho-1044305
ABSTRACT
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89610-616.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurofilament Proteins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Ann Neurol Year: 2021 Document Type: Article Affiliation country: Ana.26004

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurofilament Proteins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Ann Neurol Year: 2021 Document Type: Article Affiliation country: Ana.26004