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Obesity and SARS-CoV-2: A population to safeguard.
Watanabe, Mikiko; Risi, Renata; Tuccinardi, Dario; Baquero, Claudia J; Manfrini, Silvia; Gnessi, Lucio.
  • Watanabe M; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
  • Risi R; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
  • Tuccinardi D; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Baquero CJ; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
  • Manfrini S; Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Gnessi L; Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
Diabetes Metab Res Rev ; : e3325, 2020 Apr 21.
Article in English | MEDLINE | ID: covidwho-99621
ABSTRACT
Evidence has lately emerged regarding an increased risk of SARS-CoV-2 with worse prognosis in patients with obesity, especially among the young. Weight excess is a well-established respiratory disease risk factor, and the newly reported correlation is therefore unsurprising. The underlying pathophysiology is likely multi-stranded, ranging from complement system hyperactivation, increased Interleukin-6 secretion, chronic inflammation, presence of comorbidities such as diabetes and hypertension, and a possible local, detrimental effect within the lung. Further understanding the link between obesity and SARS-CoV-2 is crucial, as this could aid proper tailoring of immunomodulatory treatments, together with improving stratification among those possibly requiring critical care.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Diabetes Metab Res Rev Journal subject: Endocrinology / Metabolism Year: 2020 Document Type: Article Affiliation country: Dmrr.3325

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Diabetes Metab Res Rev Journal subject: Endocrinology / Metabolism Year: 2020 Document Type: Article Affiliation country: Dmrr.3325