Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study.
Metabolism
; 112: 154344, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-997340
ABSTRACT
OBJECTIVE:
We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. METHODS AND STUDYDESIGN:
Participants (Nâ¯=â¯337,802, aged 56.4⯱â¯8.1â¯yr; 55.1% women) underwent biomedical assessments at baseline as part of the UK Biobank prospective cohort study. The outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020.RESULTS:
At follow up, 649 cases COVID-19 were recorded. In multivariable adjusted analyses, risk of COVID-19 was elevated in people with undiagnosed diabetes at baseline (A1Câ¯≥â¯6.5%) (risk ratioâ¯=â¯2.68; 95% confidence interval 1.66, 4.33) and poorly controlled (A1Câ¯≥â¯8.6%) diagnosed diabetes (1.91;1.04, 3.52). There was a dose-dependent increase in risk of COVID-19 with increasing A1C, that persisted in multivariable adjusted models (per SD [0.9%] 1.07; 1.03, 1.11; p[trend]â¯<â¯0.001).CONCLUSION:
In this large community-based sample, higher levels of A1C within the normal range were a risk factor for COVID-19. Glucose regulation may play a key role in immune responses to this infection. Undiagnosed cases of diabetes in the general community may present a particularly high risk.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
COVID-19
/
Hospitalization
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Metabolism
Year:
2020
Document Type:
Article
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