Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches.
Signal Transduct Target Ther
; 5(1): 293, 2020 12 24.
Article
in English
| MEDLINE | ID: covidwho-997815
ABSTRACT
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization. As of 4 August 2020, more than 18 million confirmed infections had been reported globally. Most patients have mild symptoms, but some patients develop respiratory failure which is the leading cause of death among COVID-19 patients. Endothelial cells with high levels of angiotensin-converting enzyme 2 expression are major participants and regulators of inflammatory reactions and coagulation. Accumulating evidence suggests that endothelial activation and dysfunction participate in COVID-19 pathogenesis by altering the integrity of vessel barrier, promoting pro-coagulative state, inducing endothelial inflammation, and even mediating leukocyte infiltration. This review describes the proposed cellular and molecular mechanisms of endothelial activation and dysfunction during COVID-19 emphasizing the principal mediators and therapeutic implications.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Endothelial Cells
/
Pandemics
/
COVID-19
/
Inflammation
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Signal Transduct Target Ther
Year:
2020
Document Type:
Article
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