Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies.
Biochem Soc Trans
; 49(1): 341-352, 2021 02 26.
Article
in English
| MEDLINE | ID: covidwho-997958
ABSTRACT
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA genomes known to date. Apart from the primary sequence encoding for all the viral proteins needed for the generation of new viral particles, certain regions of CoV genomes are known to fold into stable structures, controlling several aspects of CoV life cycle, from the regulation of the discontinuous transcription of subgenomic mRNAs, to the packaging of the genome into new virions. Here we review the current knowledge on CoV RNA structures, discussing it in light of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Ribosomal
/
RNA, Viral
/
Genome, Viral
/
Coronavirus
/
Frameshifting, Ribosomal
/
SARS-CoV-2
Limits:
Humans
Language:
English
Journal:
Biochem Soc Trans
Year:
2021
Document Type:
Article
Affiliation country:
BST20200670
Similar
MEDLINE
...
LILACS
LIS