Clinical analysis of 132 cases COVID-19 from Wuhan.
Medicine (Baltimore)
; 99(44): e22847, 2020 Oct 30.
Article
in English
| MEDLINE | ID: covidwho-20238619
ABSTRACT
Numerous cases of pneumonia from a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China during December 2019.We determined the correlations of patient parameters with disease severity in patients with COVID-19.A total of 132 patients from Wuhan Fourth Hospital who had COVID-19 from February 1 to February 29 in 2020 were retrospectively analyzed.Ninety patients had mild disease, 32 had severe disease, and 10 had critical disease. The severe/critical group was older (Pâ<â.05), had a higher proportion of males (Pâ<â.05), and had a greater mortality rate (0% vs 61.9%, Pâ<â.05). The main symptoms were fever (nâ=â112, 84.8%) and cough (nâ=â96, 72.7%). Patients were treated with antiviral agents (nâ=â94, 71.2%), antibiotics (nâ=â92, 69.7%), glucocorticoids (nâ=â46, 34.8%), intravenous immunoglobulin (nâ=â38, 27.3%), and/or traditional Chinese medicine (nâ=â40, 30.3%). Patients in the severe/critical group received mechanical ventilation (nâ=â22, 16.7%) or high-flow nasal can-nula oxygen therapy (nâ=â6, 4.5%). Chest computed tomography (CT) indicated bilateral pneumonia in all patients. Relative to the mild group, the severe/critical group had higher levels of leukocytes, C-reactive protein (CRP), procalcitonin (PCT), D-dimer, B-type natriuretic peptide (BNP), liver enzymes, and myocardial enzymes (Pâ<â.05), and decreased levels of lymphocytes and blood oxygen partial pressure (Pâ<â.05).The main clinical symptoms of patients from Wuhan who had COVID-19 were fever and cough. Patients with severe/critical disease were more likely to be male and elderly. Disease severity correlated with increased leukocytes, CRP, PCT, BNP, D-dimer, liver enzymes, and myocardial enzymes, and with decreased lymphocytes and blood oxygen partial pressure.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
Type of study:
Observational study
/
Prognostic study
Topics:
Traditional medicine
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Medicine (Baltimore)
Year:
2020
Document Type:
Article
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