The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity.

Ovsyannikova, Inna G; Haralambieva, Iana H; Crooke, Stephen N; Poland, Gregory A; Kennedy, Richard B

Ovsyannikova, Inna G; Haralambieva, Iana H; Crooke, Stephen N; Poland, Gregory A; Kennedy, Richard B.

Ovsyannikova IG; Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Haralambieva IH; Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Crooke SN; Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Poland GA; Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
Kennedy RB; Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.

Immunol Rev ; 296(1): 205-219, 2020 07.

Article in English | MEDLINE | ID: covidwho-998975

ABSTRACT

ABSTRACT

This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/immunology; Disease Resistance/genetics; Genetic Predisposition to Disease; Host-Pathogen Interactions/genetics; Pneumonia, Viral/immunology; Animals; Betacoronavirus/pathogenicity; COVID-19; Coronavirus Infections/epidemiology; Coronavirus Infections/genetics; Coronavirus Infections/virology; Host-Pathogen Interactions/immunology; Humans; Middle East Respiratory Syndrome Coronavirus/immunology; Middle East Respiratory Syndrome Coronavirus/pathogenicity; Pandemics; Pneumonia, Viral/epidemiology; Pneumonia, Viral/genetics; Pneumonia, Viral/virology; Severe acute respiratory syndrome-related coronavirus/immunology; Severe acute respiratory syndrome-related coronavirus/pathogenicity; SARS-CoV-2; Severe Acute Respiratory Syndrome/genetics; Severe Acute Respiratory Syndrome/virology

Keywords

COVID-19; GWAS; HLA; SARS; SARS-CoV-2; alleles; coronavirus; genes; genetic variation; genome-wide association study; immunogenetics; polymorphisms; severe acute respiratory syndrome; single nucleotide; systems biology; vaccine

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Genetic Predisposition to Disease / Host-Pathogen Interactions / Disease Resistance / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Immunol Rev Year: 2020 Document Type: Article Affiliation country: Imr.12897

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