Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Sci Immunol
; 5(54)2020 12 23.
Article
in English
| MEDLINE | ID: covidwho-999191
Semantic information from SemMedBD (by NLM)
1. Infected PROCESS_OF Health Personnel
2. Antibodie PART_OF C0018724
3. Asymptomatic Infections COEXISTS_WITH Symptoms
4. Antigens PART_OF 2019 novel coronavirus
5. Antibodie ASSOCIATED_WITH C5203670
6. Antibodie PART_OF C0027361
7. Epidermal cGVHD Score 2 PROCESS_OF Persons
8. COVID-19 PROCESS_OF Persons
9. Infected PROCESS_OF Health Personnel
10. Antibodies, Neutralizing PART_OF Health Personnel
11. Asymptomatic Infections COEXISTS_WITH Symptoms
12. Antigens PART_OF 2019 novel coronavirus
13. Antibodies, Neutralizing ASSOCIATED_WITH COVID-19
14. Antibodies, Neutralizing PART_OF Persons
15. Epidermal cGVHD Score 2 PROCESS_OF Persons
16. COVID-19 PROCESS_OF Persons
ABSTRACT
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Antibodies, Neutralizing
/
Asymptomatic Infections
/
COVID-19
Type of study:
Observational study
/
Prevalence study
/
Randomized controlled trials
/
Risk factors
Limits:
Humans
Language:
English
Year:
2020
Document Type:
Article
Affiliation country:
Sciimmunol.abf3698
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