Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Sci Immunol
; 5(54)2020 12 23.
Article
in English
| MEDLINE | ID: covidwho-2161788
ABSTRACT
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Antibodies, Neutralizing
/
Asymptomatic Infections
/
COVID-19
Type of study:
Observational study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Year:
2020
Document Type:
Article
Affiliation country:
SCIIMMUNOL.ABF3698
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