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Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Reynolds, Catherine J; Swadling, Leo; Gibbons, Joseph M; Pade, Corinna; Jensen, Melanie P; Diniz, Mariana O; Schmidt, Nathalie M; Butler, David K; Amin, Oliver E; Bailey, Sasha N L; Murray, Sam M; Pieper, Franziska P; Taylor, Stephen; Jones, Jessica; Jones, Meleri; Lee, Wing-Yiu Jason; Rosenheim, Joshua; Chandran, Aneesh; Joy, George; Di Genova, Cecilia; Temperton, Nigel; Lambourne, Jonathan; Cutino-Moguel, Teresa; Andiapen, Mervyn; Fontana, Marianna; Smit, Angelique; Semper, Amanda; O'Brien, Ben; Chain, Benjamin; Brooks, Tim; Manisty, Charlotte; Treibel, Thomas; Moon, James C; Noursadeghi, Mahdad; Altmann, Daniel M; Maini, Mala K; McKnight, Áine; Boyton, Rosemary J.
  • Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK.
  • Swadling L; Division of Infection and Immunity, University College London, London, UK.
  • Gibbons JM; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Pade C; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Jensen MP; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Diniz MO; Division of Infection and Immunity, University College London, London, UK.
  • Schmidt NM; Division of Infection and Immunity, University College London, London, UK.
  • Butler DK; Department of Infectious Disease, Imperial College London, London, UK.
  • Amin OE; Division of Infection and Immunity, University College London, London, UK.
  • Bailey SNL; Department of Infectious Disease, Imperial College London, London, UK.
  • Murray SM; Department of Infectious Disease, Imperial College London, London, UK.
  • Pieper FP; Department of Infectious Disease, Imperial College London, London, UK.
  • Taylor S; National Infection Service, Public Health England, Porton Down, UK.
  • Jones J; National Infection Service, Public Health England, Porton Down, UK.
  • Jones M; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Lee WJ; Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Rosenheim J; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Chandran A; Division of Infection and Immunity, University College London, London, UK.
  • Joy G; Division of Infection and Immunity, University College London, London, UK.
  • Di Genova C; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.
  • Lambourne J; Viral Pseudotype Unit, Medway School of Pharmacy, Chatham Maritime, Kent, UK.
  • Cutino-Moguel T; Department of Infection, Barts Health NHS Trust, London, UK.
  • Andiapen M; Department of Virology, Barts Health NHS Trust, London, UK.
  • Fontana M; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Smit A; Royal Free London NHS Foundation Trust, London, UK.
  • Semper A; Royal Free London NHS Foundation Trust, London, UK.
  • O'Brien B; National Infection Service, Public Health England, Porton Down, UK.
  • Chain B; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • Brooks T; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Manisty C; German Heart Centre and Charité University, Berlin, Germany.
  • Treibel T; Division of Infection and Immunity, University College London, London, UK.
  • Moon JC; National Infection Service, Public Health England, Porton Down, UK.
  • Noursadeghi M; Institute of Cardiovascular Science, University College London, UK.
  • Altmann DM; Institute of Cardiovascular Science, University College London, UK.
  • Maini MK; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
  • McKnight Á; Institute of Cardiovascular Science, University College London, UK.
Sci Immunol ; 5(54)2020 12 23.
Article in English | MEDLINE | ID: covidwho-999191
Semantic information from SemMedBD (by NLM)
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2. Antibodie PART_OF C0018724
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3. Asymptomatic Infections COEXISTS_WITH Symptoms
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4. Antigens PART_OF 2019 novel coronavirus
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6. Antibodie PART_OF C0027361
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7. Epidermal cGVHD Score 2 PROCESS_OF Persons
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9. Infected PROCESS_OF Health Personnel
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10. Antibodies, Neutralizing PART_OF Health Personnel
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ABSTRACT
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Neutralizing / Asymptomatic Infections / COVID-19 Type of study: Observational study / Prevalence study / Randomized controlled trials / Risk factors Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abf3698

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Antibodies, Neutralizing / Asymptomatic Infections / COVID-19 Type of study: Observational study / Prevalence study / Randomized controlled trials / Risk factors Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abf3698