Your browser doesn't support javascript.
Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave.
Barallat, Jaume; Fernández-Rivas, Gema; Quirant-Sánchez, Bibiana; González, Victoria; Doladé, Maria; Martinez-Caceres, Eva; Piña, Monica; Matllo, Joan; Estrada, Oriol; Blanco, Ignacio.
  • Barallat J; Servei d'Anàlisis Clínics i Bioquímica, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
  • Fernández-Rivas G; Servei de Microbiologia, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
  • Quirant-Sánchez B; Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • González V; Servei d'Immunologia, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
  • Doladé M; Departament de Biologia Celular, Fisiologia i Immunologia, Universitat Autònoma Barcelona, Barcelona, Spain.
  • Martinez-Caceres E; Servei de Microbiologia, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
  • Piña M; Centre d'Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Departament de Salut, Generalitat de Catalunya, Badalona, Spain.
  • Matllo J; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Estrada O; Servei d'Anàlisis Clínics i Bioquímica, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
  • Blanco I; Servei d'Immunologia, Laboratori Clínic de la Metropolitana Nord, Gerència Territorial Metropolitana Nord, Institut Català de la Salut, Barcelona, Spain.
PLoS One ; 15(12): e0244348, 2020.
Article in English | MEDLINE | ID: covidwho-999840
Semantic information from SemMedBD (by NLM)
1. IMPACT gene PART_OF Persons
Subject
IMPACT gene
Predicate
PART_OF
Object
Persons
2. Health Personnel TREATS Patients
Subject
Health Personnel
Predicate
TREATS
Object
Patients
3. immunoglobulin G PART_OF 2019 novel coronavirus
Subject
immunoglobulin G
Predicate
PART_OF
Object
2019 novel coronavirus
4. Health Personnel LOCATION_OF Specimen Type - Serum
Subject
Health Personnel
Predicate
LOCATION_OF
Object
Specimen Type - Serum
5. Specimen Type - Serum LOCATION_OF immunoglobulin G
Subject
Specimen Type - Serum
Predicate
LOCATION_OF
Object
immunoglobulin G
6. Negative PROCESS_OF Participant
Subject
Negative
Predicate
PROCESS_OF
Object
Participant
7. Equivocal result PROCESS_OF Participant
Subject
Equivocal result
Predicate
PROCESS_OF
Object
Participant
8. Hospitals LOCATION_OF Work
Subject
Hospitals
Predicate
LOCATION_OF
Object
Work
9. General Population LOCATION_OF SARS-CoV-2 IgG
Subject
General Population
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
10. Health Personnel LOCATION_OF SARS-CoV-2 IgG
Subject
Health Personnel
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
11. IMPACT gene PART_OF Persons
Subject
IMPACT gene
Predicate
PART_OF
Object
Persons
12. Health Personnel TREATS Patients
Subject
Health Personnel
Predicate
TREATS
Object
Patients
13. immunoglobulin G PART_OF 2019 novel coronavirus
Subject
immunoglobulin G
Predicate
PART_OF
Object
2019 novel coronavirus
14. Health Personnel LOCATION_OF Specimen Type - Serum
Subject
Health Personnel
Predicate
LOCATION_OF
Object
Specimen Type - Serum
15. Specimen Type - Serum LOCATION_OF immunoglobulin G
Subject
Specimen Type - Serum
Predicate
LOCATION_OF
Object
immunoglobulin G
16. Negative PROCESS_OF Participant
Subject
Negative
Predicate
PROCESS_OF
Object
Participant
17. Equivocal result PROCESS_OF Participant
Subject
Equivocal result
Predicate
PROCESS_OF
Object
Participant
18. Hospitals LOCATION_OF Work
Subject
Hospitals
Predicate
LOCATION_OF
Object
Work
19. General Population LOCATION_OF SARS-CoV-2 IgG
Subject
General Population
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
20. Health Personnel LOCATION_OF SARS-CoV-2 IgG
Subject
Health Personnel
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
ABSTRACT

BACKGROUND:

The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic, infecting millions of individuals, with an unprecedented impact in health care systems worldwide. Healthcare workers are one of the risk groups that need to be well protected, due to their strategic role in patient management, presently and in prevention of healthcare needs for future outbreaks. Here, we present the results of the first SARS-CoV-2 seroprevalence study in the Northern Metropolitan Area of Barcelona, Spain.

METHODS:

IgG SARS-CoV-2 antibodies were analyzed in serum samples from 7563 healthcare workers of the Northern Metropolitan Area of Barcelona. Samples were collected after the first pandemic wave (from May 4th to May 22nd, 2020) and were analyzed by automated chemiluminescence assays. All samples were tested for IgG anti-S1/S2. Participant samples with negative or equivocal results but with analytical signals above the limit of detection and/or previously confirmed COVID-19 diagnosis were also tested for IgG anti-Nucleocapsid.

RESULTS:

A total of 779 of 7563 (10.3%) healthcare workers were positive for anti-SARS-CoV-2 IgG (specific for either S1/S2 or N antigens). No significant differences were observed between those working at primary care or at the reference hospital. Interestingly, among 341 participants with a confirmed COVID-19 diagnosis, 36 (10.55%) tested negative for SARS-CoV-2 IgG (both S1/S2 and recombinant N antigen).

CONCLUSION:

Seroprevalence of anti-SARS-CoV-2 IgG in the healthcare workers of the North Metropolitan Area of Barcelona was higher than in the general population in the same geographical area. Safety measures have to be stressed in order to protect these essential workers from future pandemic waves.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244348

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244348