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Coronary calcium scoring assessed on native screening chest CT imaging as predictor for outcome in COVID-19: An analysis of a hospitalized German cohort.
Zimmermann, Gregor S; Fingerle, Alexander A; Müller-Leisse, Christina; Gassert, Felix; von Schacky, Claudio E; Ibrahim, Tareq; Laugwitz, Karl-Ludwig; Geisler, Fabian; Spinner, Christoph; Haller, Bernhard; Makowski, Markus R; Nadjiri, Jonathan.
  • Zimmermann GS; Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Fingerle AA; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Müller-Leisse C; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Gassert F; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • von Schacky CE; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Ibrahim T; Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Laugwitz KL; Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Geisler F; Department of Internal Medicine II, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Spinner C; Department of Internal Medicine II, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Haller B; Institute of Medical Informatics, Statistics and Epidemiology, Technical University of Munich, Munich, Germany.
  • Makowski MR; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Nadjiri J; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
PLoS One ; 15(12): e0244707, 2020.
Article in English | MEDLINE | ID: covidwho-999850
ABSTRACT

BACKGROUND:

Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby, cardiovascular comorbidity has a major impact on mortality. We investigated whether coronary calcification as a marker for coronary artery disease (CAD) is appropriate for risk prediction in COVID-19.

METHODS:

Hospitalized patients with COVID-19 (n = 109) were analyzed regarding clinical outcome after native computed tomography (CT) imaging for COVID-19 screening. CAC (coronary calcium score) and clinical outcome (need for intensive care treatment or death) data were calculated following a standardized protocol. We defined three endpoints critical COVID-19 and transfer to ICU, fatal COVID-19 and death, composite endpoint critical and fatal COVID-19, a composite of ICU treatment and death. We evaluated the association of clinical outcome with the CAC. Patients were dichotomized by the median of CAC. Hazard ratios and odds ratios were calculated for the events death or ICU or a composite of death and ICU.

RESULTS:

We observed significantly more events for patients with CAC above the group's median of 31 for critical outcome (HR 1.97[1.09,3.57], p = 0.026), for fatal outcome (HR 4.95[1.07,22.9], p = 0.041) and the composite endpoint (HR 2.31[1.28,4.17], p = 0.0056. Also, odds ratio was significantly increased for critical outcome (OR 3.01 [1.37, 6.61], p = 0.01) and for fatal outcome (OR 5.3 [1.09, 25.8], p = 0.02).

CONCLUSION:

The results indicate a significant association between CAC and clinical outcome in COVID-19. Our data therefore suggest that CAC might be useful in risk prediction in patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronary Artery Disease / Vascular Calcification / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244707

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronary Artery Disease / Vascular Calcification / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0244707