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Prevalence of Health Care and Hospital Worker SARS-CoV-2 IgG Antibody in a Pediatric Hospital.
Tokareva, Yekaterina; Englund, Janet A; Dickerson, Jane A; Brown, Julie C; Zerr, Danielle M; Walter, Emily; Tsogoo, Ariundari; Cappetto, Kaitlin; Valdez Gonzalez, Jaqueline; Strelitz, Bonnie; Klein, Eileen J.
  • Tokareva Y; Seattle Children's Research Institute, Seattle, Washington; and.
  • Englund JA; Seattle Children's Research Institute, Seattle, Washington; and.
  • Dickerson JA; Divisions of Infectious Diseases and.
  • Brown JC; Seattle Children's Research Institute, Seattle, Washington; and.
  • Zerr DM; Laboratory Medicine, School of Medicine, University of Washington, Seattle, Washington.
  • Walter E; Seattle Children's Research Institute, Seattle, Washington; and.
  • Tsogoo A; Emergency Medicine, Departments of Pediatrics and.
  • Cappetto K; Seattle Children's Research Institute, Seattle, Washington; and.
  • Valdez Gonzalez J; Divisions of Infectious Diseases and.
  • Strelitz B; Seattle Children's Research Institute, Seattle, Washington; and.
  • Klein EJ; Seattle Children's Research Institute, Seattle, Washington; and.
Hosp Pediatr ; 11(3): e48-e53, 2021 03.
Article in English | MEDLINE | ID: covidwho-999865
ABSTRACT

OBJECTIVES:

Asymptomatic transmission of coronavirus disease 2019 (COVID-19) in health care settings is not well understood. In this study, we aimed to determine the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies in health care and hospital workers (HCHWs) and assess how antibody levels change over time.

METHODS:

Cross-sectional study of employed HCHWs at a freestanding, urban pediatric tertiary care hospital. Employed HCHWs ≥18 years old who were asymptomatic and worked in clinical hospital locations were eligible to participate. Participants completed blood draws and surveys at baseline (between May 4, 2020, and June 2, 2020) and 2 months later (between July 6, 2020, and August 7, 2020). Surveys collected demographic information, SARS-CoV-2 exposures, and previous COVID-19 diagnosis.

RESULTS:

In total, 530 participants enrolled in and completed baseline study activities. The median age was 37 years (range 19-67 years); 86% identified as female, and 80% identified as white. Two months later, 481 (91%) HCHWs completed another survey and blood draw. Four of 5 (0.9%) seropositive subjects at baseline remained seropositive at 2 months, although 3 had decreasing IgG indices. Five (1.0%) seropositive individuals, including 4 who were previously seropositive and 1 newly seropositive, were detected 2 months later. History of positive SARS-CoV-2 polymerase chain reaction testing results (P < .001) and history of COVID-19 exposure (P < .001) were associated with presence of SARS-CoV-2 antibodies.

CONCLUSIONS:

SARS-CoV-2 antibodies were detected in 1% of HCHWs in an urban pediatric hospital in a city with moderate SARS-CoV-2 prevalence. Participants with a known previous COVID-19 diagnosis showed a decline or loss of IgG antibodies over 2 months. These results have implications for identifying those with previous exposure and for ongoing public health recommendations for ensuring workplace safety.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Health Personnel / SARS-CoV-2 / COVID-19 / Hospitals, Pediatric / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Hosp Pediatr Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Health Personnel / SARS-CoV-2 / COVID-19 / Hospitals, Pediatric / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: North America Language: English Journal: Hosp Pediatr Year: 2021 Document Type: Article