The Potential Mechanism of Prevention and Treatment of COVID-19 by Shufeng Jiedu Capsule was Studied Based on Network Pharmacology / 基于网络药理学研究疏风解毒胶囊防治新型冠状病毒肺炎的潜在作用机制

ABSTRACT

Objective To investigate the mechanism of Shufeng Jiedu Capsule (SJC) for treatment of COVID-19 based on network pharmacology. Methods Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to obtain the active components and targets information of Polygoni Cuspidati Rhizoma Et Radix, Forsythiae Fructus, Istidis Radix, Radix Bupleuri, Herba Patriniae, Verbenae Herb, Phragmitis Rhizoma and licorice in SJC. The Genecards databases were used to obtain COVID-19 targets. The meridian tropisms of each herb in SJC were collected from ETCM Database.the proteins interations network were build by STRING database. The GO and KEGG pathways were analyzed by the computer R language. Results SFC contains 8herbs, 176 compounds and the corresponding targets 237. 48 COVID-19 targets are treated by SJC. Such as IL-10, IL-6, PTGS1, PTGS2, GSK3B, STAT-1, IL-17 signaling pathway, HIF-1 signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway and VEGF signaling pathway may be potential targets and signaling pathways for the prevention and treatment of COVID-19. Conclusion The COVID-19 can treatment the potential targets and signaling pathways by the SJC, and play the role of antipyretic, anti-inflammatory, balance immunity, antiviral and so on. It will provide strong support for the later stage experiment and clinical application of SJC.

摘要

目的 运用网络药理学的研究方法，初步探讨疏风解毒胶囊防治新型冠状病毒肺炎的潜在作用机制。方法 通过中药系统药理学分析平台TCMSP搜索疏风解毒胶囊组方中虎杖、连翘、板蓝根、柴胡、败酱草、马鞭草、芦根、甘草的活性成分及对应靶点信息，运用Genecards数据库获得新冠肺炎的相关靶点信息，运用ETCM数据库查找疏风解毒胶囊每味中药的归经；利用STRING数据库绘制蛋白-蛋白互作网络图，通过计算机R语言进行GO功能富集分析及KEGG通路富集分析。结果 疏风解毒胶囊中符合条件的化合物176个，蛋白靶点237个，疏风解毒胶囊防治新型冠状病毒肺炎的潜在靶点有48个。关键靶点有IL-10、IL-6、PTGS1、PTGS2、GSK3B、STAT-1等，潜在信号通路有IL-17信号通路、HIF-1信号通路、Toll-like receptor信号通路、T cell receptor信号通路、VEGF信号通路。结论 疏风解毒胶囊可通过调控关键靶点和潜在信号通路防治新型冠状病毒肺炎，发挥解热、抗炎、平衡免疫、抗病毒等作用，为疏风解毒胶囊的后期实验和临床应用提供有力支持。