Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports
Rev. Soc. Bras. Med. Trop
; 53:e20200372-e20200372, 2020.
Article
in English
| LILACS (Americas) | ID: grc-743025
ABSTRACT
Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
Search on Google
Collection:
Databases of international organizations
Database:
LILACS (Americas)
Type of study:
Case report
/
Experimental Studies
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS