Comparative Approach to Human Auditory Synaptopathy
National Technical Information Service; 2020.
Non-conventional
in English
| National Technical Information Service | ID: grc-753518
ABSTRACT
Exposure to noise can cause damage to structures in the inner ear, often resulting in a loss of hearing. Recent findings in noise-exposedanimals raise a new specter that even moderate noise exposures may result in damage specifically located in the synaptic region betweenthe sensory cells in the cochlea and primary auditory neurons. There is no way currently that scientists and clinicians can diagnose possibleauditory synaptic damage in humans, and diagnosis is critical for the development of innovative treatments. The objective of this project isto develop a statistical model that will accurately predict the likelihood of synaptopathy in humans who have had noise exposures in theirlives. The development of the statistical model will be supported by collecting non-invasive measurements in both humans and guinea pigs.Regulatory documents supporting human and animal testing have been approved both locally and through the relevant offices of theUSAMRMC. The animal laboratory was outfitted with a new sound booth for auditory testing, and data collection is on schedule to begin shortly. Research technicians have been hired to assist in both the human and animal facilities. However, overall progress has been significantly slowed by the seven months and ongoing international pandemic.
HEALTH SERVICES; MEDICAL PERSONNEL; EAR; HEARING DISORDERS; TEST METHODS; CELLULAR STRUCTURES; DATA ACQUISITION; DEPARTMENT OF DEFENSE; DEPARTMENT OF VETERANS AFFAIRS; HEARING LOSS; OTOTOXICITY; RODENTS; SKULL; THERAPY; BIOMEDICAL RESEARCH; CELLS; DISEASES AND DISORDERS; ACQUISITION; COMPUTER PROGRAMS; COVID-19
Full text:
Available
Collection:
Databases of international organizations
Database:
National Technical Information Service
Type of study:
Prognostic study
Language:
English
Year:
2020
Document Type:
Non-conventional
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