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Role of Mitochondria in ADT-Induced Sarcopenia in Prostate Cancer Patients
National Technical Information Service; 2020.
Non-conventional in English | National Technical Information Service | ID: grc-753573
ABSTRACT
Prostate cancer (PCa) is the most common cancer among men. Androgen deprivation therapy (ADT)is the standard treatment for advanced and metastatic PCa and nearly 400,000 men remain on androgen deprivation therapy (ADT) for advanced PCa in the U.S. Unfortunately, ADT also induces a decrease in muscle mass and function, known as sarcopenia, a condition that leads to decreased endurance, increased fatigue, falls, poor health-related quality of life (HR-QOL) and increased mortality. The mechanisms underlying the development of ADT-induced sarcopenia are incompletely understood and remain a significant barrier to the development of therapies for this condition. Mitochondria play an essential role in generating the adenosine triphosphate (ATP) needed for muscle contraction and abnormalities in mitochondria function have been reported in animal models of sarcopenia. The extent to which mitochondrial dysfunction mediates ADT-induced sarcopenia and muscle dysfunction is not known. The overall goal of this proposal is to establish the role of mitochondrial dysfunction on ADT-induced sarcopenia in patients with PCa. Our hypothesis is that ADT in men with PCa will induce mitochondrial dysfunction leading to sarcopenia. To test this hypothesis, we will carry out a pilot study of men with PCa undergoing ADT (n=60).As of August 26, 2020, we have enrolled seventeen research participants in the study. Research participant recruitment and performance of study visits were impacted beginning in March due to the COVID-19 epidemic. We are following local VA and UW communications closely to ensure we meet their recommended guidelines for resuming human subjects research
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Full text: Available Collection: Databases of international organizations Database: National Technical Information Service Language: English Year: 2020 Document Type: Non-conventional

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Full text: Available Collection: Databases of international organizations Database: National Technical Information Service Language: English Year: 2020 Document Type: Non-conventional