Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora
ClinicalTrials.gov; 22/04/2020; TrialID: NCT04366089
Clinical Trial Register
| ICTRP | ID: ictrp-NCT04366089
ABSTRACT
Condition
COVID;SARS-CoV 2;Pneumonia, Viral;Coronavirus InfectionIntervention
Other Oxygen-ozone therapy, probiotic supplementation and Standard of care;Dietary Supplement SivoMixx (200 billion);Drug Azithromycin;Drug hydroxychloroquinePrimary outcome:
Delta in the number of patients requiring orotracheal intubation despite treatmentCriteria
Inclusion Criteria
- Age > 18 years
- Nasopharyngeal swab positive for COVID-19
- COVID-19 stages I - II - III (*1)
- Hospitalization in the Department of Infectious Diseases
Exclusion Criteria
- COVID-19 stages IV - V - VI (*1)
- Hospitalization in Intensive Care Units
- Pregnancy
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Patients who deny consent to the proposed treatment
- Inability to provide informed consent
- Contraindications to performing oxygen-ozone therapy
- hyperhomocysteinemia
- favism or thyroiditis
- coagulopathies
- neurodegenerative diseases
- angina (in particular Prinzmetal's angina) or with previous myocardial infarction
(*1) Compliant with indications published by
Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI).
Care pathway for the patient with COVID-19.
Section 2 - Recommendations for local management of the critically ill patient - Version 2
Available on
http//www.siaarti.it/SiteAssets/News/COVID19%20-%20documenti%20SIAARTI/Percorso%20COVID-19
%20-%20Sezione%202%20-%20Raccomandazioni%20per%20la%20gestione%20locale%20-%20Rev%202.0.pdf
Last accessed 20/04/2020
Posted on 26.03.2020
On page 2 of the previous document
"6 identified stages
- sick disease - mild COVID-19 (I stage)
- light pneumonia - mild COVID-19 (II stage)
- serious pneumonia - severe COVID-19 (III stage)
- Acute respiratory distress syndrome (ARDS) - critical COVID-19 (IV stage)
- sepsis - critical COVID-19 (V stage)
- septic shock - critical COVID-19 (VI stage)"
Collection:
Clinical trial registers
Database:
ICTRP
Topics:
Traditional medicine
Year:
2020
Document Type:
Clinical Trial Register
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