Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death

ABSTRACT

ConditionCOVID-19;Pneumonia, Viral

InterventionBiological AZD1222

Primary outcome:Number of HIV-uninfected patients with laboratory-confirmed SARS-CoV-2 illness;Number of patients with laboratory-confirmed SARS-CoV-2 illness who have been vaccinated with at least one dose

Criteria
Inclusion Criteria

- Any individual aged 18 and older eligible to receive AZ1222 vaccine following the
national immunization recommendations.

- Willing and able to provide informed consent.

Exclusion Criteria

- Any significant acute or chronic medical condition that in the opinion of the
vaccinator makes the participant unsuitable for participation in the study or
jeopardises the safety of the participant.

- Participant reports being pregnant.

- History of severe adverse reaction associated with a vaccine and/or severe allergic
reaction (e.g., anaphylaxis) to any component of the vaccine.

Test negative vaccine effectiveness case-control study

The study population consists of individuals presenting at the participating hospitals and
health centres during the study period, who

Either

- Are hospitalized (or died) for an illness consistent with possible COVID-19. Or (in
case of other hospital controls)

- Presented to the emergency department (ED) for reasons other than a COVID-19 like
illness (e.g. trauma or elective surgery).

And

- Meet the inclusion criteria.

Inclusion criteria

- Ever eligible to receive AZ1222 vaccine following the national immunization
recommendations prior to hospital admission.

And

- Willing and able to provide informed consent.

Exclusion criteria

- None