Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial

ABSTRACT

ConditionPost-COVID-19 Syndrome;Post-COVID Syndrome;Post COVID-19 Condition;Post-COVID Condition;Post COVID-19 Condition, Unspecified;Long COVID;Long Covid19

InterventionDrug Hyperbaric oxygen

Primary outcome:Physical and mental component scores of the 36-item Short Form Survey (SF-36)

Criteria
Inclusion Criteria

- Cognitive and/or physical symptoms = 12 months after acute COVID-19 infection

- Symptoms include post-exertional malaise (PEM) and/or dysautonomia as assessed by
questionnaires and/or NASA LEAN test

- Symptoms affect day-to-day life (based on SF-36 'role limitations due to physical
functioning' score of = 50 at baseline).

- Current treatment regimen is stable for at least 1 months before inclusion

Exclusion Criteria

- Unfit for hyperbaric treatment

- Previous diagnosis of ME/CFS

- Unable to provide informed consent