Your browser doesn't support javascript.
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions
Livia Perfetto; Chiara Pastrello; Noemi Del-Toro; Margaret Duesbury; Marta Iannuccelli; Max Kotlyar; Luana Licata; Birgit Meldal; Kalpana Panneerselvam; Simona Panni; Negin Rahimzadeh; Sylvie Ricard-Blum; Lukasz Salwinski; Anjali Shrivastava; Gianni Cesareni; Matteo Pellegrini; Sandra Orchard; Igor Jurisica; Henning Hermjakob; Pablo Porras.
  • Livia Perfetto; European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI)
  • Chiara Pastrello; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Can
  • Noemi Del-Toro; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Margaret Duesbury; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK. UCLA-DOE Institute, UCLA,
  • Marta Iannuccelli; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
  • Max Kotlyar; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Can
  • Luana Licata; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
  • Birgit Meldal; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Kalpana Panneerselvam; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Simona Panni; Department of Biology, Ecology and Earth Sciences, Universita della Calabria, Rende, Italy
  • Negin Rahimzadeh; UCLA-DOE Institute, UCLA, Los Angeles, USA. Providence John Wayne Cancer Institute, Santa Monica, USA
  • Sylvie Ricard-Blum; Univ Lyon, University Claude Bernard Lyon 1, INSA Lyon, CPE, Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), UMR 5246, F-69622 Vil
  • Lukasz Salwinski; UCLA-DOE Institute, UCLA, Los Angeles, USA
  • Anjali Shrivastava; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Gianni Cesareni; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
  • Matteo Pellegrini; Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, USA
  • Sandra Orchard; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Igor Jurisica; Krembil Research Institute, Data Science Discovery Centre for Chronic Diseases, University Health Network, 5KD-407, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Can
  • Henning Hermjakob; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Pablo Porras; European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Preprint in English | bioRxiv | ID: ppbiorxiv-153817
Journal article
A scientific journal published article is available and is probably based on this preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See journal article
ABSTRACT
The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are being used to understand the disease and develop effective treatments, the study of physical molecular interactions enables studying fine-grained resolution of the mechanisms behind the virus biology and the human organism response. Here we present a curated dataset of physical molecular interactions, manually extracted by IMEx Consortium curators focused on proteins from SARS-CoV-2, SARS-CoV-1 and other members of the Coronaviridae family. Currently, the dataset comprises over 2,200 binarized interactions extracted from 86 publications. The dataset can be accessed in the standard formats recommended by the Proteomics Standards Initiative (HUPO-PSI) at the IntAct database website (www.ebi.ac.uk/intact), and will be continuously updated as research on COVID-19 progresses.
Full text: Available Collection: Preprints Database: bioRxiv Document Type: Preprint Language: English Year: 2020

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Collection: Preprints Database: bioRxiv Document Type: Preprint Language: English Year: 2020
...